IQOS – a heat-not-burn (HnB) tobacco product – chemical composition and possible impact on oxidative stress and inflammatory response. A systematic review

IF 2.8 4区医学 Q2 TOXICOLOGY

Toxicology Mechanisms and Methods Pub Date : 2020-02-01 DOI:10.1080/15376516.2019.1669245

P. Kopa, R. Pawliczak

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引用次数: 33

Abstract

Abstract Objectives: This work attempts to summarize current knowledge about IQOS, the heat-not-burn tobacco products, their chemical composition and possible impact on oxidative stress and inflammatory response. Materials and Methods: The literature search was performed between January and April 2019 by a combination of terms: ‘IQOS smoking’, ‘IQOS cigarette’, ‘I quit original smoking cigarette’, ‘heat-not-burn products’, ‘HnB tobacco products’. Results: The aim of IQOS system is to minimalize the exposure of its smokers to dangerous substances present in cigarette smoke and to lower the probability of development of tobacco-related diseases. As current studies suggest, this new heat-not-burn tobacco product emits significantly lower concentrations of tar, carbonyls, VOCs, CO, free radicals or nitrosamines when compared to conventional cigarette, and thus it may reduce health risk for smokers. However, it does not eliminate this risk of development of tobacco-related diseases. Discussion: For conventional tobacco smokers the IQOS products may be an alternative option, which helps to reduce exposure to hazardous and potentially hazardous constituents. However, for never-smokers using the IQOS cigarettes may develop an addiction or increase exposition to some substances, which may increase probability of tobacco-related diseases. Moreover, emission of unexpected substances depends on device cleaning strategy and puff regiments. Conclusions: There is only limited data about IQOS effect on smokers’ health. The future investigation, especially comparison with healthy never-smokers or study of chronic exposure to IQOS, is needed.

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IQOS -一种加热不燃烧(HnB)烟草产品-化学成分及其对氧化应激和炎症反应的可能影响。系统回顾

摘要目的:本工作试图总结目前关于IQOS，加热不燃烧烟草产品，其化学成分及其对氧化应激和炎症反应的可能影响的知识。材料和方法:文献检索于2019年1月至4月期间进行，检索词包括:“IQOS吸烟”、“IQOS卷烟”、“我戒掉了原卷烟”、“加热不燃烧产品”、“HnB烟草产品”。结果:IQOS系统的目的是最大限度地减少吸烟者对香烟烟雾中存在的危险物质的暴露，降低烟草相关疾病的发生概率。目前的研究表明，与传统卷烟相比，这种新的加热不燃烧烟草产品排放的焦油、羰基、挥发性有机化合物、一氧化碳、自由基或亚硝胺的浓度明显较低，因此可以降低吸烟者的健康风险。然而，它并没有消除这种发生烟草相关疾病的风险。讨论:对于传统吸烟者来说，IQOS产品可能是一种替代选择，有助于减少接触有害和潜在有害成分。然而，对于从不吸烟的人来说，使用IQOS香烟可能会上瘾或增加对某些物质的接触，这可能会增加与烟草有关的疾病的可能性。此外，意外物质的排放取决于设备清洁策略和抽吸团。结论:IQOS对吸烟者健康的影响数据有限。未来的调查，特别是与健康的不吸烟者或长期暴露于IQOS的研究进行比较，是必要的。

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来源期刊

Toxicology Mechanisms and Methods TOXICOLOGY-

自引率

3.10%

发文量

期刊介绍： Toxicology Mechanisms and Methods is a peer-reviewed journal whose aim is twofold. Firstly, the journal contains original research on subjects dealing with the mechanisms by which foreign chemicals cause toxic tissue injury. Chemical substances of interest include industrial compounds, environmental pollutants, hazardous wastes, drugs, pesticides, and chemical warfare agents. The scope of the journal spans from molecular and cellular mechanisms of action to the consideration of mechanistic evidence in establishing regulatory policy. Secondly, the journal addresses aspects of the development, validation, and application of new and existing laboratory methods, techniques, and equipment. A variety of research methods are discussed, including: In vivo studies with standard and alternative species In vitro studies and alternative methodologies Molecular, biochemical, and cellular techniques Pharmacokinetics and pharmacodynamics Mathematical modeling and computer programs Forensic analyses Risk assessment Data collection and analysis.