Donor Factors Affecting Short Term Graft Outcome in Live Donor Kidney Transplantation

Abstract

IntroductionSince the beginning of renal transplant, the objective has been to increase the patient and graft survival, bothshort term and long term. Data relating to donor factors affecting short term survival at 6 months in live donorkidney transplantation has been scarce. This single center study tries to examine the predictors of short termgraft outcome at six months in recipients of live donor kidney transplants and explore which donor characteristicsare the most useful in predicting the post-transplant graft function in Nepalese population.MethodsAll patients who underwent kidney transplantation between May 2015 to July 2016 were included in the study.The patients who expired during follow were excluded. The clinical and laboratory parameters of the donors wererecorded. The recipients were followed up for six months post transplantation. The eGFR of the recipients and theoccurrence of rejection were recorded at the end of six months post transplantation.ResultsA total of 82 donor-recipient pairs underwent living donor renal transplantation at our hospital during the studyperiod. One recipient who expired during follow up was excluded. The mean age of donor was 45.20 ± 11.226years of which 55 (67.9%) were female and 26 (32.1 %) were male. The mean eGFR of the donor calculatedfrom Cockcroft Gault equation was 81.98 ± 18.11. The eGFR of the recipient at the end of six months posttransplantation calculated form the MDRD equation was 67.76 ± 20.94. A total of 7 patients (8.6%) had rejectionthat were biopsy proven. Only donor eGFR was found to be significantly associated with eGFR of the recipientat six months post transplantation (p=0.034). Body mass index of the donor was significantly associated withrejection in the recipient at six months post transplantation (p=0.011).ConclusionOur study demonstrates that the donor eGFR and body mass index are independent and important factorsaffecting the short term graft outcome at six months post transplantation.KeywordsBody mass index, donor eGFR, graft outcome, renal transplantation