Renal Thrombotic Microangiopathy Associated with Carfilozomib Use in Treatment of Multiple Myeloma

Abstract

Carfilzomib is a newer class of selective proteasome inhibitor approved by FDA in 2012. It is used for the treatment of refractory multiple myeloma in patients who have received two prior therapies. We report a case of drug induced thrombotic microangiopathy associated with carfilzomib in a patient with refractory multiple myeloma.