Amide Synthesis through Selective Partial Hydrolysis of Nitriles in Alkaline Media

Abstract

Amides were obtained through partial hydrolysis of nitriles, using two different energy sources, traditional heating with solvent reflux and ultrasound. The reaction was performed at micro and semi-micro scales and at different reaction time with both energy sources. Yield was determined through gas chromatography, in the case of micro-scale and weight loss in the case of semi-micro scale.