Toxic Metals Transfer from Heating Coils to e-liquids: Safety Assessment of Popular e-cigarettes in Jordan

Q3 Pharmacology, Toxicology and Pharmaceutics

Jordan Journal of Pharmaceutical Sciences Pub Date : 2023-07-24 DOI:10.35516/jjps.v16i2.1466

Ala A. Alhusban, Samah A. Ata, Lama A. Hamadneh, O. Tarawneh, Haneen Abuzaid, Sokiyna Albustanji, Mohammad K. Awad

{"title":"Toxic Metals Transfer from Heating Coils to e-liquids: Safety Assessment of Popular e-cigarettes in Jordan","authors":"Ala A. Alhusban, Samah A. Ata, Lama A. Hamadneh, O. Tarawneh, Haneen Abuzaid, Sokiyna Albustanji, Mohammad K. Awad","doi":"10.35516/jjps.v16i2.1466","DOIUrl":null,"url":null,"abstract":"The rate of smokers in Jordan has been among the highest globally. Electronic Nicotine Delivery systems (ENDs) are considered helpful in smoking cessation but also have the potential for metals exposure resulting from their transfer from the metallic coils to the e-liquid upon use. Metal exposure is associated with severe health outcomes. We sought to assess the levels of toxic metals (Cr, Cd, Pb, Ni and Al) transfer from two of the most popular coils used in ENDs among users in Jordan. The validated inductively coupled plasma-optical emission spectroscopy (ICP-OES) with limit of detections (LODs) of 0.10, 0.90, 0.15, 0.13 and 1.00 mg.kg−1 was employed to measure the levels of toxic metals in the e-liquid samples. Following a repetitive usage of coils in both tank and pod systems for five continuous days, the cumulative amount of toxic metals; Ni, Cr, Al and Pb levels were significantly increased in all e-liquids used (p < 0.0001) compared to the fresh unheated samples. The obtained results showed a time-dependent increase of metals transfer from coils to e-liquids, thus highlighting the need for additional studies to re-assess the safety claims of using ENDs for smoking cessation. \n ","PeriodicalId":14719,"journal":{"name":"Jordan Journal of Pharmaceutical Sciences","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Jordan Journal of Pharmaceutical Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.35516/jjps.v16i2.1466","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Pharmacology, Toxicology and Pharmaceutics","Score":null,"Total":0}

引用次数: 0

Abstract

The rate of smokers in Jordan has been among the highest globally. Electronic Nicotine Delivery systems (ENDs) are considered helpful in smoking cessation but also have the potential for metals exposure resulting from their transfer from the metallic coils to the e-liquid upon use. Metal exposure is associated with severe health outcomes. We sought to assess the levels of toxic metals (Cr, Cd, Pb, Ni and Al) transfer from two of the most popular coils used in ENDs among users in Jordan. The validated inductively coupled plasma-optical emission spectroscopy (ICP-OES) with limit of detections (LODs) of 0.10, 0.90, 0.15, 0.13 and 1.00 mg.kg−1 was employed to measure the levels of toxic metals in the e-liquid samples. Following a repetitive usage of coils in both tank and pod systems for five continuous days, the cumulative amount of toxic metals; Ni, Cr, Al and Pb levels were significantly increased in all e-liquids used (p < 0.0001) compared to the fresh unheated samples. The obtained results showed a time-dependent increase of metals transfer from coils to e-liquids, thus highlighting the need for additional studies to re-assess the safety claims of using ENDs for smoking cessation.

查看原文本刊更多论文

有毒金属从加热线圈转移到电子液体：约旦流行电子烟的安全评估

约旦的吸烟率一直是全球最高的。电子尼古丁输送系统（ENDs）被认为有助于戒烟，但也有可能因使用时从金属线圈转移到电子液体中而导致金属暴露。金属暴露与严重的健康后果有关。我们试图评估约旦用户在ENDs中使用的两种最受欢迎的线圈中有毒金属（Cr、Cd、Pb、Ni和Al）的转移水平。采用经验证的电感耦合等离子体发射光谱法（ICP-OES），检测限（LOD）为0.10、0.90、0.15、0.13和1.00 mg/kg−1，测量电子液体样品中的有毒金属水平。连续五天在储罐和吊舱系统中重复使用线圈后，有毒金属的累积量；与未加热的新鲜样品相比，所有使用的电子液体中的Ni、Cr、Al和Pb水平均显著升高（p＜0.0001）。所获得的结果显示，金属从线圈转移到电子液体的时间依赖性增加，因此强调需要进行额外的研究来重新评估使用ENDs戒烟的安全性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Jordan Journal of Pharmaceutical Sciences Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

1.70

自引率

0.00%

发文量

期刊介绍： The Jordan Journal of Pharmaceutical Sciences (JJPS) is a scientific, bi-annual, peer-reviewed publication that will focus on current topics of interest to the pharmaceutical community at large. Although the JJPS is intended to be of interest to pharmaceutical scientists, other healthy workers, and manufacturing processors will also find it most interesting and informative. Papers will cover basic pharmaceutical and applied research, scientific commentaries, as well as views, reviews. Topics on products will include manufacturing process, quality control, pharmaceutical engineering, pharmaceutical technology, and philosophies on all aspects of pharmaceutical sciences. The editorial advisory board would like to place an emphasis on new and innovative methods, technologies, and techniques for the pharmaceutical industry. The reader will find a broad range of important topics in this first issue.