Preliminary assessment of influence of calcium alginate beads on the dissolution of meloxicam

IF 0.4 4区医学 Q4 PHARMACOLOGY & PHARMACY

Acta poloniae pharmaceutica Pub Date : 2023-06-29 DOI:10.32383/appdr/162533

Barbara Jadach, Weronika Świetlik, Ł. Majchrzycki

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Abstract

The purpose of the study was to evaluate the preparation of alginate-based microparticles with meloxicam (MLX). A poorly soluble substance classified to BCS class II, it was chosen as a model substance. The ionotropic gelation was the process used for the formation of microparticles. The impact of the carrier on the dissolution of MLX from this formulation was also investigated. Study was realized in few steps: preparation of polymer particles containing suspended MLX in their structure; drying them in various conditions (room temperature, freeze drying); morphology characterization and then assessment of impact of polymer on dissolution of the model substance. Also, DDSolver software was used for checking the similarity of release profiles. Validated UV-Vis spectrophotometric method was used for MLX determination on different steps of work. As it showed, calcium alginate particles were successfully prepared with ionotropic gelation. The drying method of prepared particles has a substantial impact on the release profiles of meloxicam, and these formulations significantly improve the MLX release from this form of the delivery system.

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藻酸钙微珠对美洛昔康溶出度影响的初步评价

本研究旨在评价美洛昔康（MLX）制备海藻酸盐基微粒的工艺。它是一种难溶性物质，属于BCS II类，被选为模型物质。离子致凝胶化是用于形成微粒的过程。还研究了载体对MLX从该制剂中溶解的影响。研究分几个步骤实现：制备结构中含有悬浮MLX的聚合物颗粒；在各种条件下干燥（室温、冷冻干燥）；形态表征，然后评估聚合物对模型物质溶解的影响。此外，DDSolver软件用于检查发布配置文件的相似性。经验证的紫外-可见分光光度法用于不同工作步骤的MLX测定。结果表明，采用离子致凝胶法成功制备了海藻酸钙颗粒。制备颗粒的干燥方法对美洛昔康的释放特性有很大影响，这些制剂显著改善了MLX从这种形式的递送系统中的释放。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta poloniae pharmaceutica 医学-药学

CiteScore

0.80

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The international journal of the Polish Pharmaceutical Society is published in 6 issues a year. The journal offers Open Access publication of original research papers, short communications and reviews written in English, in all areas of pharmaceutical sciences. The following areas of pharmaceutical sciences are covered: Analysis, Biopharmacy, Drug Biochemistry, Drug Synthesis, Natural Drugs, Pharmaceutical Technology, Pharmacology and General. A bimonthly appearing in English since 1994, which continues “Acta Poloniae Pharmaceutica”, whose first issue appeared in December 1937. The war halted the activity of the journal’s creators. Issuance of “Acta Poloniae Pharmaceutica” was resumed in 1947. From 1947 the journal appeared irregularly, initially as a quarterly, then a bimonthly. In the years 1963 – 1973 alongside the Polish version appeared the English edition of the journal. Starting from 1974 only works in English are published in the journal. Since 1995 the journal has been appearing very regularly in two-month intervals (six books a year). The journal publishes original works from all fields of pharmacy, summaries of postdoctoral dissertations and laboratory notes.

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