The Hematology Profiles of Adults Affiliated with Epilepsy after Receiving Valproic Acid Therapy

Open Access Macedonian Journal of Medical Sciences Pub Date : 2023-05-23 DOI:10.3889/oamjms.2023.11617

Christiyan Naydenov, Ivan Stanchev Mindov

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引用次数: 0

Abstract

AIM: Epilepsy is a socially significant neurological disease spread all over the world. Valproic acid (VPA) is one of the most used antiepileptic drug (AED) for treatment which has some side effects on hematology field. A nowadays update to the adult safety information is needed. The current aim is to conduct a cross-sectional study and to describe the hematology profile of adults with epilepsy treated by VPA. MATERIALS AND METHODS: Data collection was done retrospectively and includes characteristics of the subjects such as age, gender, electroencephalography (EEG) finding, duration of VPA treatment, type of treatment, and hematology profile. We report 50 subjects treated by VPA at least 1 year. RESULTS: The mean age is 46, 4 years, 50% male and 50% female. About 92% were generalized tonic-clonic seizure. Seven percent were partial complex epilepsy. Twenty-four EEG results were abnormal (48%). We found 4 cases (7%) of thrombocytopenia at therapeutic dose and 8 cases (16%) of mild anemia. DISCUSSION: Gender differences were eliminated by having the same number of participants of each gender. The EEG findings were almost equally normal and abnormal. Reported drug reactions due to VPA were thrombocytopenia and anemia. Thrombocytopenia requires discontinuation of VPA.

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成人癫痫患者接受丙戊酸治疗后的血液学分析

目的:癫痫是一种广泛传播的具有社会意义的神经系统疾病。丙戊酸(VPA)是目前应用最广泛的抗癫痫药物之一，在血液学领域有一定的副作用。现在需要更新成人安全信息。目前的目的是进行一项横断面研究，并描述成人癫痫患者接受VPA治疗的血液学概况。材料和方法:回顾性收集资料，包括受试者的特征，如年龄、性别、脑电图(EEG)发现、VPA治疗持续时间、治疗类型和血液学特征。我们报告了50例接受VPA治疗至少1年的患者。结果:患者平均年龄46.4岁，男女各占50%。约92%为全身性强直-阵挛性发作。7%为部分复杂癫痫。脑电图异常24例(48%)。我们发现4例(7%)治疗剂量的血小板减少症和8例(16%)轻度贫血。讨论:男女参与者人数相同，消除了性别差异。脑电图结果几乎同样正常和异常。报告的VPA引起的药物反应为血小板减少和贫血。血小板减少症需要停用VPA。

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来源期刊

Open Access Macedonian Journal of Medical Sciences Medicine-Medicine (all)

自引率

0.00%

发文量

1225

期刊介绍： Open Access Macedonian Journal of Medical Sciences (OAMJMS) [formerly known as Macedonian Journal of Medical Sciences] is a top-tier open access medical science journal published by the ID Design 2012/DOOEL Skopje, Rajko Zhinzifov No 48, 1000 Skopje, Republic of Macedonia. OAMJMS is an international, modern, general medical journal covering all areas in the medical sciences, from basic studies to large clinical trials and cost-effectiveness analyses. We publish mostly human studies that substantially enhance our understanding of disease epidemiology, etiology, and physiology; the development of prognostic and diagnostic technologies; trials that test the efficacy of specific interventions and those that compare different treatments; and systematic reviews. We aim to promote translation of basic research into clinical investigation, and of clinical evidence into practice. We publish occasional studies in animal models when they report outstanding research findings that are highly clinically relevant. Our audience is the international medical community as well as educators, policy makers, patient advocacy groups, and interested members of the public around the world. OAMJMS is published quarterly online version. The Open Access Macedonian Journal of Medical Sciences (OAMJMS) publishes Medical Informatics, Basic Science, Clinical Science, Case Report, Brief Communication, Public Health, Public Policy, and Review Article from all fields of medicine and related fields. This journal also publishes, continuously or occasionally, the bibliographies of the members of the Society, medical history, medical publications, thesis abstracts, book reviews, reports on meetings, information on future meetings, important events and dates, and various headings which contribute to the development of the corresponding scientific field.