Relationship between phosphatase and tensin homolog (PTEN) expression in high grade glioma and histopathologic findings

Q4 Medicine

Romanian Journal of Neurology/ Revista Romana de Neurologie Pub Date : 2021-12-31 DOI:10.37897/rjn.2021.4.7

Nasim Hayati, H. Tabriz, E. Nazar, R. Gorji

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引用次数: 2

Abstract

Introduction. Malignant glioma is resistant brain tumor to treatment and considered by aggressiveness that fails successful resection. Molecular pathways including PTEN related with tumor behavior. Materials and methods. We studied the immunohistochemical expression of PTEN in 32 brain surgical resection specimens with different histologic grades. All samples were from pathology department of Sina hospital in Tehran-Iran from 2020-2021. Results. From 32 patients, 21 (65.6%) had no PTEN staining. There was significant relationship between high age and no PTEN expression and average age with no PTEN staining was 54.05±14.01 years (P value: 0.044). There was significant relationship between necrosis in histopathologic evaluation with no PTEN staining (P value: 0.016). Also, there was no significant relationship between sex, tumor’s size, Tumor’s site, tumor’s grade, and primary or secondary type of tumor with PTEN staining (P value > 0.05). Conclusion. PTEN expression related to histopathologic features such as necrosis and age. PTEN can be introduced as an important prognostic indicator in high grade.

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高级别胶质瘤中磷酸酶和紧张素同源物(PTEN)表达的关系及组织病理学表现

介绍。恶性神经胶质瘤是一种对治疗有抵抗力的脑肿瘤，被认为具有侵袭性，不能成功切除。包括PTEN在内的分子通路与肿瘤行为相关。材料和方法。我们研究了32例不同组织学分级的脑外科切除标本中PTEN的免疫组织化学表达。所有样本均来自2020-2021年伊朗德黑兰新浪医院病理科。结果。32例患者中，21例(65.6%)未见PTEN染色。PTEN未表达与高年龄有显著相关性，PTEN未表达的平均年龄为54.05±14.01岁(P值:0.044)。坏死与PTEN未染色有显著相关性(P值:0.016)。PTEN染色与性别、肿瘤大小、肿瘤部位、肿瘤分级、原发性或继发性肿瘤类型无显著相关性(P值0.05)。结论。PTEN表达与组织病理特征如坏死和年龄有关。PTEN可作为高分级的重要预后指标引入。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Romanian Journal of Neurology/ Revista Romana de Neurologie Medicine-Neurology (clinical)

CiteScore

0.40

自引率

0.00%

发文量

审稿时长

4 weeks

期刊介绍： ROMANIAN JOURNAL OF NEUROLOGY (Revista Română de Neurologie), the official journal of the Romanian Society of Neurology, was founded in 2001, being a prestigious scientific journal that provides a high quality in terms of scientific content, but also the editorial and graphic aspect, both through an impartial process of selection, evaluation and correction of articles (peer review procedure), as well as providing editorial, graphic and printing conditions at the highest level. In order to increase the scientific standards of the journal, special attention was paid to the improvement of the quality of the published materials. Guidance articles, clinical trials and case studies are structured in several sections: reviews, original articles, case reports, images in neurology. All articles are published entirely in English. A team of reputable medical professionals in the field of neurology is involved in a rigorous peer review process that complies with international ethics and quality rules in the academic world.