Age, and non-age-related cytoarchitectural changes in the brain of some Nigerian cattle

Q4 Veterinary
J. Shawulu, J. Hambolu, James Olopade3, S. Ojo, A. Balkema-Buschmann, Reiner Ulrich
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引用次数: 0

Abstract

Brain is the most vulnerable organ in the body to the ageing processes which operates at variable levels between organs and species. In this study we examine brains histopathologically for architectural changes in four Nigerian cattle breeds. Brains from 246 cattle (Bunaji=80, Muturu=78, Rahaji=62 and Sokoto Gudali=26), aged 1–≥12years were examined at 8 different neuroanatomical locations. All the cattle used were obtained from Abattoir in Ibadan, Nigeria. They were examined at ante-mortem and those without clinical signs suggestive of neurological disease were sampled. Major changes observed were intracellular accumulation of substances (61.4%), neuronal and or axonal degenerations and loss (51.6%), perivascular cuffing (50.0%), extracellular accumulation of substances (29.7%), hypercellularity (19.1%) and spongy state (0.4%), malacia (0.0%), demyelination (0.0%) in 233 cattle. Intraneuronal vacuolations (35%), lipofuscin accumulation (42%), axonal spheroids (50%), inflammatory changes (50%), and brain sand (22%). Although perivascular cuffing was high, there was low incidence of lymphocytic infiltration in the pineal gland in both sexes. Intracellular accumulation of substances, neuronal and or axonal degenerations and loss, and extracellular accumulation of substances display levels of significant changes with age (p<0.0001). Changes starts at the age of 2 years in life in these breeds of cattle due probably to the adverse stress exerted by the tropical climate. The description of histological findings in the brain of symptomless cattle in the present study provides a useful background for diagnostic bovine neuropathology in the tropics.
一些尼日利亚牛大脑中年龄和非年龄相关的细胞结构变化
大脑是人体中最易受衰老过程影响的器官,在不同器官和物种之间,衰老的程度各不相同。在这项研究中,我们检查了四个尼日利亚牛品种的大脑组织病理学结构变化。选取1 ~ 12岁的246头牛(Bunaji=80, Muturu=78, Rahaji=62, Sokoto Gudali=26),在8个不同的神经解剖位置进行脑检查。所有使用的牛均来自尼日利亚伊巴丹的屠宰场。他们在死前被检查,那些没有提示神经系统疾病的临床症状的人被抽样。在233头牛中观察到的主要变化是细胞内物质积聚(61.4%),神经元和/或轴突变性和丧失(51.6%),血管周围弯曲(50.0%),细胞外物质积聚(29.7%),细胞高(19.1%)和海绵状(0.4%),软化(0.0%),脱髓鞘(0.0%)。神经元内空泡形成(35%),脂褐素积聚(42%),轴突球体(50%),炎症改变(50%)和脑砂(22%)。尽管松果体的血管周围弯曲率很高,但淋巴细胞浸润的发生率在两性中都很低。细胞内物质积累、神经元和/或轴突变性和损失以及细胞外物质积累水平随着年龄的增长而发生显著变化(p<0.0001)。这些品种的牛在2岁时开始发生变化,这可能是由于热带气候施加的不利压力。在本研究中,对无症状牛脑的组织学发现的描述为热带地区诊断牛神经病理学提供了有用的背景。
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来源期刊
Brazilian Journal of Veterinary Pathology
Brazilian Journal of Veterinary Pathology Veterinary-Veterinary (miscellaneous)
CiteScore
0.60
自引率
0.00%
发文量
24
期刊介绍: The Brazilian Journal of Veterinary Pathology is the official electronic periodical of the Brazilian Association of Veterinary Pathology. The purpose of the BJVP is to publish original full papers, short communications, case reports, letters, reviews (by invited experts) and abstracts of scientific meetings. The preferable subjects is natural and experimental pathology. All the articles are submitted to scientific reviewers.
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