T-helper and natural killer cells’ disturbance in active alopecia areata

A. Younes, Refaat Hammad, Ali Sobhy
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Abstract

Background and aim Alopecia areata (AA) is a common nonscarring hair disease targeting the hair follicles during the anagen phase, leading to hair loss. The etiology of AA is still unclear; however, evidence revealed the association of this disease with immune disturbance. Therefore, we aimed in this study to evaluate the level of natural killer (NK) and T-helper 1 (Th1) cells in the peripheral circulation of patients with different subtypes of AA during the active stage in comparison with the controls. Patients and methods Venous blood samples from 50 female patients and 50 healthy-controls were collected to evaluate the level of Th1 and NK cells using flow cytometry. Results Patients with active patchy AA, alopecia totalis, and alopecia universalis were associated with a lower level of circulating Th1 and NK cells when compared with the controls. Conclusion The observed reduction in the circulating Th1 and NK cells indicates the autoimmune nature of the disease. Also, we highlight the cellular shift from the peripheral circulation to the lesion site during the active stage; however, more research is required to reveal the exact mechanism for this phenomenon.
活动性斑秃患者辅助T细胞和自然杀伤细胞的紊乱
背景与目的斑秃(AA)是一种常见的非瘢痕性毛发疾病,在毛发生长阶段以毛囊为目标,导致脱发。AA的病因尚不清楚;然而,有证据显示这种疾病与免疫紊乱有关。因此,我们在本研究中旨在评估不同亚型AA患者在活动期外周循环中自然杀伤(NK)和t辅助1 (Th1)细胞的水平,并与对照组进行比较。患者与方法采集50例女性患者和50例健康对照者静脉血,采用流式细胞术检测Th1和NK细胞水平。结果与对照组相比,活动性斑块性AA、全秃和普遍秃患者外周血Th1和NK细胞水平较低。结论观察到的循环Th1和NK细胞的减少提示疾病的自身免疫性。此外,我们强调在活跃期细胞从外周循环转移到病变部位;然而,需要更多的研究来揭示这一现象的确切机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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审稿时长
34 weeks
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