Azoxymethane-dextran sulfate sodium induces colorectal cacner mouse model

Abstract

Colorectal cancer is one of the most common malignancies around the world that seriously affects human life and health. Most studies used cell line experiments to investigate the characteristics of colorectal cancer, but the foundation of colorectalcancer (CRC) in situ mouse model would better imitate the occurrence the process of CRC, and improve the credibility of basic experiments greatly. In the present, azoxymethane/dextran sulfate sodium (AOM/DSS)-induced cancer model is widely use in the building of CRC animal model, but there are quite differences exist in the quantities of research. As a result, this review will concisely introduce the process and assessment of the AOM/DSS-induced mouse CRC model in order to provide a comprehensive reference for the one does this ailment model. Key words: Azoxymethane/dextran sulfate sodium; Inflammation-induced cancer; Model, mouse; Assessment of model