Do estrogen antagonists and anti-androgens prevent the COVID-19’s pulmonary involvement?

Abstract

Male and female hormones are upregolators of expression of Angiotensin-converting Enzyme 2 (ACE2) gene. This short article proposes a hypothesis about the potential effect of estrogen antagonists and anti-androgens in preventing pulmonary involvement in COVID-19 infection through their downregulatory effect on ACE2 expression.