A comprehensive review on the synthesis and functionalization of pyrrolopyrazines and its derivatives

Abstract

Developing some methods for the synthesis of various N-heterocyclic compounds has been the subject of intense interest regarding their significant pharmaceutical applications. Pyrrolopyrazines, as an important group of fused N-heterocycles, possess a variety of biological effects. With the rise in the number of papers on the synthesis of pyrrolopyrazine derivations and evaluation of their biological activities, a more in-depth understanding of the most recent and authentic information about the chemistry and synthetic approaches of this class of N-heterocyclic compounds might be beneficial. This review provides a broad survey of the reported synthetic approaches for the preparation of pyrrolopyrazines. The focus of this study is on the annulation methods starting from pyrrole and pyrazine cores. Also, the chemistry of the pyrrolopyrazines scaffold is briefly discussed.