Clinical pathology analysis of 30 patients with mushroom shaped uveal melanoma

Q4 Medicine

中华眼底病杂志 Pub Date : 2020-02-25 DOI:10.3760/CMA.J.ISSN.1005-1015.2020.02.008

Ju Zhang, W. Wei, Bin Li, Xiaolin Xu

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Abstract

Objective To analyze the clinical pathological features of mushroom shaped uveal melanoma. Methods Retrospective clinical study. From June 2001 to Aprilh 2013, pathological sections from 102 eyes of 102 patients with uveal melanoma diagnosed in Beijing Tongren Eye Center were included in the study. The sections were divided into group A (mushroom shaped uveal melanoma, 30 eyes) and group B (flat, hemisperical and spherical uveal melanoma, 72 eyes). The height-to-base ratio was calculated. The tumors size was divided into small, medium and large according to the standards of American Multicentre Study of Ocular Melanoma. The tumor cell type was divided into spindle, epithelioid, mixed and others by Improved Callender taxonomy. Motic Med 6.0 software was used to collect and measure the images. The retinal thinning rate of group A and B was compared by χ2 test. Results In group A, large size in 19 eyes (63.3%), medium size in 11 eyes (36.7%). In group B, large size in 49 eyes (68.1%), medium size in 16 eyes (22.%), small size in 7 eyes(9.7%). In group A and B, the average tumor base diameter were 14.2±5.1 mm and 18.7±6.4 mm, respectively; the average tumor height were 10.0±2.1 mm and 7.6±3.9, respectively; the height-to-base ratio were 0.77±0.29 and 0.44±0.28, respectively. In group A, spindle type in 24 eyes (80.0%), epithelioid type in 1 eye (3.3%), mixed type in 5 eyes (16.7%). In group B, spindle type in 52 eyes (72.2%), epithelioid type in 5 eyes (6.9%), mixed type in 11 eyes (15.3%), and others in 4 eyes (5.6%). The proportion of retinal thinning were 73.3% (22 eyes) and 29.2% (21 eyes) in group A and B, respectively. The difference in the proportion of retinal thinning between group A and B was significant (χ2=16.94, P=0.000). Conclusion The height of the tumor increased rapidly and the retinal thinning rate is high in mushroom shaped uveal melanoma. Key words: Uveal neoplasma/pathology; Melanoma/pathology

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蘑菇状葡萄膜黑色素瘤30例临床病理分析

目的分析蕈状葡萄膜黑色素瘤的临床病理特点。方法回顾性临床研究。研究纳入2001年6月至2013年4月在北京同仁眼科中心诊断的102例葡萄膜黑色素瘤患者102只眼的病理切片。切片分为A组(蘑菇状葡萄膜黑色素瘤，30眼)和B组(扁平、半球形、球形葡萄膜黑色素瘤，72眼)。计算了高基比。肿瘤大小按照美国多中心眼黑色素瘤研究标准分为小、中、大。改进Callender分类法将肿瘤细胞分为梭形、上皮样、混合型和其他类型。采用Motic Med 6.0软件采集和测量图像。A、B组视网膜变薄率比较采用χ2检验。结果A组大尺寸19眼(63.3%)，中尺寸11眼(36.7%)。B组大尺寸49眼(68.1%)，中尺寸16眼(22.%)，小尺寸7眼(9.7%)。A、B组平均瘤底直径分别为14.2±5.1 mm和18.7±6.4 mm;平均肿瘤高度分别为10.0±2.1 mm和7.6±3.9 mm;高基比分别为0.77±0.29和0.44±0.28。A组纺锤型24眼(80.0%)，上皮样型1眼(3.3%)，混合型5眼(16.7%)。B组纺锤体型52眼(72.2%)，上皮样型5眼(6.9%)，混合型11眼(15.3%)，其他4眼(5.6%)。A组和B组视网膜变薄比例分别为73.3%(22眼)和29.2%(21眼)。A组与B组视网膜变薄比例比较差异有统计学意义(χ2=16.94, P=0.000)。结论蕈状葡萄膜黑色素瘤肿瘤高度增加快，视网膜变薄率高。关键词:葡萄膜肿瘤/病理;黑色素瘤/病理学

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来源期刊

中华眼底病杂志 Medicine-Ophthalmology

CiteScore

0.40

自引率

0.00%

发文量

5383

期刊介绍： Chinese Journal of Ocular Fundus Diseases is the only scientific journal in my country that focuses on reporting fundus diseases. Its purpose is to combine clinical and basic research, and to give equal importance to improvement and popularization. It comprehensively reflects the leading clinical and basic research results of fundus disease disciplines in my country; cultivates professional talents in fundus disease, promotes the development of fundus disease disciplines in my country; and promotes academic exchanges on fundus disease at home and abroad. The coverage includes clinical and basic research results of posterior segment diseases such as retina, uveal tract, vitreous body, visual pathway, and internal eye diseases related to systemic diseases. The readers are medical workers and researchers related to clinical and basic research of fundus diseases. According to the journal retrieval report of the Chinese Institute of Scientific and Technological Information, the comprehensive ranking impact factor and total citation frequency of the Chinese Journal of Ocular Fundus Diseases have been among the best in the disciplines of ophthalmology, otolaryngology, and ophthalmology in my country for many years. The papers published have been included in many important databases at home and abroad, such as Scopus, Peking University Core, and China Science Citation Database (CSCD).