Comparative study between sugammedex and neostigmine as a reversal agent of rocuronium for pediatric patients 2-12 years old going for surgery under general anaesthesia

Cardiometry Pub Date : 2023-05-04 DOI:10.18137/cardiometry.2023.27.181193

Hussam Abed, A. Abdelaziz

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引用次数: 0

Abstract

Aim. The neuromuscular blocker has long been used during surgical procedures. The neuromuscular blockade produced by rocuronium can be reversed with sugammadex and neostigmine as reversal agents. This systematic review aims to determine the impact of sugammadex and neostigmine comparison as a reversal agent of rocuronium for pediatric patients 2-12 years old going for surgery under general anesthesia. Materials and Methods. This review examined recent studies assessing the impact of sugammadex and neostigmine comparison as a reversal agent of rocuronium for pediatric patients 2-12 years old going for surgery under general anesthesia. Data were searched from Google Scholar, PubMed, Hindawi, Anesthesiology, MEDLINE, and CENTRAL using keywords’ General Anesthesia,’ ‘Reversal Agent,’ ‘Rocuronium for Pediatric Patients,’ ‘Neuromuscular Blockers,’ ‘Sugammadex and Neostigmine,’ ‘Role of Analgesics.’ The review followed PRISMA guidelines. Results. The initial search for publications comparing sugammadex and neostigmine as a reversal agent of rocuronium for pediatric patients yielded 9000 papers, from which 600 were selected. The reviews’ articles were further analyzed to ensure they were pertinent to the Comparative Impact of Reversal Agents (Sugammadex And Neostigmine) of Rocuronium for Pediatric Patients. Around 319 references were examined for their potential applicability to the medical field of anesthesia. A total of 15 articles were included, with preference given to those published from 2014 to 2023 during the last ten years. Conclusion. The particular relaxant-binding medication promptly and successfully alleviates rocuronium-induced neuromuscular blockade in pediatric surgery patients. Considering the study’s outcomes, it can be concluded that sugammadex may restore any level of steroidal muscle relaxant-induced neuromuscular block faster than neostigmine.

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糖美德与新斯的明作为罗库溴铵逆转剂在2-12岁小儿全麻手术中的比较研究

目标神经肌肉阻滞剂长期以来一直在外科手术中使用。罗库产生的神经肌肉阻滞可用sugammadex和新斯的明作为拮抗剂进行拮抗。本系统综述旨在确定sugammadex和新斯的明作为罗库拮抗剂对2-12岁全麻下接受手术的儿童患者的影响。材料和方法。这篇综述考察了最近的研究，评估了sugammadex和新斯的明作为罗库拮抗剂对2-12岁全麻下接受手术的儿童患者的影响。数据来自Google Scholar、PubMed、Hindawi、麻醉学、MEDLINE和CENTRAL，关键词为“全身麻醉”、“逆转剂”、“罗库用于儿童患者”、“神经肌肉阻滞剂”、“Sugammadex和新斯的明”、“镇痛作用”审查遵循了PRISMA指南。后果首次检索比较sugammadex和新斯的明作为罗库拮抗剂用于儿科患者的出版物，共获得9000篇论文，从中选择了600篇。对综述的文章进行了进一步分析，以确保它们与罗库拮抗剂（Sugammadex和新斯的明）对儿童患者的比较影响有关。对大约319篇参考文献进行了检查，以确定其在麻醉医学领域的潜在适用性。共收录了15篇文章，优先考虑过去十年中2014年至2023年发表的文章。结论这种特殊的松弛剂结合药物能迅速成功地缓解罗库诱导的小儿外科患者的神经肌肉阻滞。考虑到研究结果，可以得出结论，sugammadex可以比新斯的明更快地恢复任何水平的类固醇肌肉松弛剂诱导的神经肌肉阻滞。

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来源期刊

Cardiometry MEDICAL LABORATORY TECHNOLOGY-

自引率

0.00%

发文量

审稿时长

6 weeks

期刊介绍： Cardiometry is an open access biannual electronic journal founded in 2012. It refers to medicine, particularly to cardiology, as well as oncocardiology and allied science of biophysics and medical equipment engineering. We publish mainly high quality original articles, reports, case reports, reviews and lectures in the field of the theory of cardiovascular system functioning, principles of cardiometry, its diagnostic methods, cardiovascular system therapy from the aspect of cardiometry, system and particular approaches to maintaining health, engineering peculiarities in cardiometry developing. The interdisciplinary areas of the journal are: hemodynamics, biophysics, biochemistry, metrology. The target audience of our Journal covers healthcare providers including cardiologists and general practitioners, bioengineers, biophysics, medical equipment, especially cardiology diagnostics device, developers, educators, nurses, healthcare decision-makers, people with cardiovascular diseases, cardiology and engineering universities and schools, state and private clinics. Cardiometry is aimed to provide a wide forum for exchange of information and public discussion on above scientific issues for the mentioned experts.