Role of interleukin-17A in endodontic disease

Abstract

Background: Endodontic disease is a complicated condition marked by inflammation of the apical tissues and is influenced by microbial, immunological, and environmental variables. Inflammatory cells, proinflammatory, and immunoregulatory cytokines are all recruited as part of the intricate immunological host response that occurs here; one of these cytokines is interleukin-17A (IL-17A). Objectives: This study aimed to determine the concentration of IL-17A by Enzyme Linked ImmunoSorbent Assay (ELISA) in the saliva of patients with endodontic disease to find the correlation between IL-17A and endodontic disease. Materials and Methods: The samples are collected from 60 patients (n = 60) with an age range of 20–50 years. The samples are collected from specialized dental centers and private clinics throughout the time period (December 2021–February 2022). The control samples are 20 (n = 20). The rate of samples was divided between males and females with ratios of 43.33% and 56.66%, respectively. Results: The result showed that the concentration of IL-17A was increased in patients compared with the control P-value (0.000). The difference in age showed no effect on the results of this study. Conclusion: This study showed that proinflammatory cytokines start immune responses in pulp tissues after bacterial infections and imply IL-17A endodontic illness.