Neuroprotective Impact Of Zingerone And Gramine On Scopolamine-Induced Amnesia Model

Abstract

Progressive memory loss is a symptom of many dangerous neurological diseases, such as Alzheimer's disease and forgetfulness. The goal of this study was to see how well bioactive molecules worked in animal models of amnesia caused by scopolamine. Ginger has a lot of Zingerone (Zn), which makes up about 9.25% of the total amount. Gramine (Ga) is a nonterpenoid indole alkaloid that is found in plants like barley and wheat. It is also known as donaxine. Acute toxicity tests were done on both of the drugs. As an animal model for study scopolamine induced amnesia in rat were selected and as behavioural evaluation the Morris water maze (MWM) and elevated plus maze were used to measure behavioural changes (EPM). In case of biochemical evaluation were the glutathione (GSH), lipid peroxidation (LPO), catalase (CAT), and AchE in the serum levels were performed. Histopathological imaging also performed. The animals were administered as per following grouping Zn (75,125,250 mg/kg p.o.) and Ga (13, 27.5,55 mg/kg), standard administered donepezil (1 mg/kg p. o.)  In This Zn, Ga and Donepezil reading demonstrate significant improvement in antioxidant defence and reversed the biochemical (LPO, GSH), enzymatic (AchE) and behavioural changes which was observed by MWM and EPM as compared to Positive control so as per above observation Zn and Ga significantly fixed the memory problems caused by scopolamine so based on the above discussion, both drugs may be able to fight Alzheimer's.