Epidemiological investigation of adenovirus pneumonia in children in Hunan province

中国小儿急救医学 Pub Date : 2019-10-20 DOI:10.3760/CMA.J.ISSN.1673-4912.2019.10.008

Qin Liu, Leyun Xie, Bing Zhang, L. Zhong, Tian Yu

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引用次数: 4

Abstract

Objective To investigate the detection results and epidemiological characteristics of human adenovirus (HAdV) among children with community acquired pneumonia (CAP) in Hunan province. Methods A descriptive retrospective survey was conducted to investigate the clinical epidemiological data of 33 056 children with CAP admitted to the Children′s Medical Center of Hunan People′s Hospital from May 1st, 2014 to April 30th, 2019.The seasonal distribution and demographic characteristics of HAdV infection were analyzed. Results (1) A total of 33 056 children with CAP were included in this study.A total of 3 770 children with HAdV positive were detected, with a total detection rate of 11.40% (3 770/33 056). From May 2014 to April 2019, the detection rates of adenovirus in different years were 13.76%, 8.57%, 7.94%, 9.53%, 12.36% and 24.75% respectively.Adenovirus detection rate reached its peak in 2019.(2) The detection rate of HAdV among male children were higher than that among female children (χ2= 6.374, P=0.012). Among 3 770 children with HAdV infection, 3 036 (80.53%) were from 6 months to 5 years old.The detection rate of adenovirus were different in different age groups.The highest detection rate was 16.65% in 3 to 5 years old group (χ2=526.494, P<0.001). Among children with severe pneumonia, the detection rate of adenovirus was 18.43% (415/2 252). The detection rate of adenovirus was the highest in the age group of 6 months to 1 years, and the difference was statistically significant(χ2=71.485, P<0.001). (3) The detection rate of adenovirus was the lowest in autumn, and the other three seasons were all high- incidence seasons (χ2= 268.744, P<0.001). (4) The hospitalization days of adenovirus pneumonia were longer than those of non-adenovirus pneumonia (Z=-10.419, P<0.001). Conclusion The prevalence of HAdV infection is related to age, season and sex.The susceptibility of adenovirus varies with severity of pneumonia.We should be vigilant against the outbreak of adenovirus infection characterized by years. Key words: Community acquired pneumonia; Adenovirus; Children; Epidemiology

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湖南省儿童腺病毒肺炎流行病学调查

目的了解湖南省社区获得性肺炎（CAP）患儿中人腺病毒（HAdV）的检测结果及流行病学特征。方法采用描述性回顾性调查方法，对湖南省人民医院儿童医学中心2014年5月1日至2019年4月30日收治的33056例CAP患儿的临床流行病学资料进行调查，分析HAdV感染的季节分布和人口学特征。结果（1）本研究共纳入33056例CAP患儿。共检测到3770例HAdV阳性儿童，总检出率为11.40%（3770/33056）。2014年5月至2019年4月，不同年份腺病毒检出率分别为13.76%、8.57%、7.94%、9.53%、12.36%和24.75%。腺病毒检测率在2019年达到峰值。（2）男性儿童的HAdV检测率高于女性儿童（χ2=6.374，P=0.012）。在3770名感染HAdV的儿童中，6个月至5岁的儿童有036人（80.53%）。不同年龄组腺病毒检出率不同。3～5岁组腺病毒检出率最高，为16.65%（χ2=526.494，P＜0.001），在重症肺炎患儿中腺病毒的检出率为18.43%（415/2 252）。腺病毒的检出率在6个月至1岁年龄组最高，差异有统计学意义（χ2=71.485，P<0.001）。（3）秋季腺病毒检出率最低，其他三个季节均为高发季节（χ2=268.744，P＜0.001）。（4）腺病毒性肺炎住院天数明显长于非腺病毒肺炎（Z=10.419，P＜0.01）。腺病毒的易感性随肺炎的严重程度而变化。我们应该警惕以年份为特征的腺病毒感染的爆发。关键词：社区获得性肺炎；腺病毒；儿童；流行病学

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来源期刊

中国小儿急救医学

自引率

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发文量

6226

期刊介绍： Chinese Journal of Neurology was established in 1955, the predecessor of which is Chinese Journal of Neurology and Psychiatry. Chinese Journal of Neurology and Psychiatry has been indexed by MEDLINE until 1996, when it was divided into two journals, Chinese Journal of Neurology, and Chinese Journal of Psychiatry. Chinese Journal of Neurology is now indexed by EM, SCOPUS, AJ, WPRIM, CNKI, Wanfang Data, CSCD, etc. The impact factor of the journal is 2.755 in 2017, ranking the first among all neurological and psychological journals in China and among all the 142 medical journals published by the Chinese Medical Association. The journal is available both in print and online.