Liquid crystal nanoparticles for commercial drug delivery

IF 4.8 3区材料科学 Q2 CHEMISTRY, PHYSICAL

Liquid Crystals Reviews Pub Date : 2017-07-03 DOI:10.1080/21680396.2017.1361874

J. Mo, G. Milleret, Mamatha Nagaraj

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引用次数: 50

Abstract

ABSTRACT Liquid crystals (LCs) are an intermediate state of matter that exists between conventional solids and liquids. They are vital to the existence of life as several critical components in living organisms such as cell wall and biochemical fluids are liquid crystalline in nature. Drug delivery based on LCs is a vast field of research. In recent years there has been a huge leap in interest into using LCs, particularly lyotropic liquid crystals (LLCs), as nanoparticles (cubosomes and hexosomes) for drug delivery applications. Such nanoparticle-based drug delivery promise efficient, controlled and target selective release of drugs. This paper reviews the concepts and techniques involved in LLC-based drug delivery. The influence of physical properties of LCs on the drug carrier design and efficiency, key aspects of the methods used to identify, characterize and analyse lyotropic nanoparticles and the feasibility of production of nanoparticles for their widespread usage are discussed. The study suggests that LC-based nanoparticles have the potential to revolutionize drug delivery industry, however a reliable method for production of nanoparticles on a large scale needs to be explored further.

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用于商业药物递送的液晶纳米粒子

摘要液晶是介于传统固体和液体之间的一种中间物质状态。它们对生命的存在至关重要，因为生物体中的几个关键组成部分，如细胞壁和生物化学流体，在自然界中都是液晶的。基于LC的药物递送是一个广阔的研究领域。近年来，人们对使用LC，特别是溶致液晶（LLCs）作为纳米颗粒（立方体和己体）用于药物递送应用的兴趣有了巨大的飞跃。这种基于纳米颗粒的药物递送有望实现药物的有效、可控和靶向选择性释放。本文综述了基于LLC的药物递送的概念和技术。讨论了LCs的物理性质对药物载体设计和效率的影响，用于识别、表征和分析溶致性纳米颗粒的方法的关键方面，以及生产广泛使用的纳米颗粒的可行性。这项研究表明，基于LC的纳米颗粒有可能彻底改变药物递送行业，然而，大规模生产纳米颗粒的可靠方法还需要进一步探索。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Liquid Crystals Reviews CHEMISTRY, PHYSICALCRYSTALLOGRAPHY&n-CRYSTALLOGRAPHY

CiteScore

7.60

自引率

5.90%

发文量

期刊介绍： Liquid Crystals Reviews publishes review articles on all aspects of liquid crystal fundamentals and applied science, including experimental and theoretical studies of physical and chemical properties, molecular design and synthesis and engineering of liquid crystal devices. The Journal fosters cross-disciplinary exchange of ideas, encouraging authors to present material at a level accessible to specialists from other fields of science and engineering. Liquid Crystals Reviews provides the scientific community, in both academia and industry, with a publication of standing, guaranteed by the Editors and by the International Editorial Board who are active scientists in the worldwide liquid crystal community.