Exercise, Advanced Glycation End Products, and Their Effects on Cardiovascular Disorders: A Narrative Review

IF 1 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS
Heart and Mind Pub Date : 2022-07-01 DOI:10.4103/hm.hm_31_22
S. Hooshiar, Helia Esmaili, A. Taherian, S. Jafarnejad
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引用次数: 5

Abstract

Lifelong accumulation of advanced glycation end products (AGEs) is linked to cardiovascular disease (CVD). As a result of AGEs, cardiovascular dysfunction develops and progresses via two main mechanisms: cross-linking AGEs with tissue proteins and binding of AGEs to their receptor for AGE (RAGE). In addition, the formation of atherosclerotic plaques in these patients may be due to increased oxidative stress, leading to an elevation in blood circulation and tissue AGEs. Increasing physical activity is a critical approach among the different strategies to manage the deleterious effects of these changes caused by disease. Exercise prevents the accumulation of AGEs and slows the progression of chronic disease sequels. Exercise reduces AGE levels through a reduction of insulin sensitivity, fat mass, inflammation, and RAGE expression. An improvement in glucose metabolism and glycemic control are also other possible explanations. Reduced peripheral insulin resistance may attenuate AGE accumulation. Physical exercise causes more antioxidant enzyme secretion and reduces oxidative stress. Antioxidant and anti-inflammatory endothelial function is improved by exercise. After exercise, subendothelial matrix stiffness decreases, and endothelial function is improved. In this current study, the association between AGEs and exercise and their interaction effects on CVD are discussed.
运动、晚期糖基化终产物及其对心血管疾病的影响:一项叙述性综述
晚期糖基化终产物(AGEs)的终生积累与心血管疾病(CVD)有关。由于AGEs,心血管功能障碍通过两种主要机制发展和发展:AGEs与组织蛋白的交联和AGEs与其AGE受体(RAGE)的结合。此外,这些患者动脉粥样硬化斑块的形成可能是由于氧化应激增加,导致血液循环和组织AGEs升高。在管理疾病引起的这些变化的有害影响的不同策略中,增加体育活动是一种关键方法。运动可以防止AGEs的积累,减缓慢性病后遗症的进展。运动通过降低胰岛素敏感性、脂肪量、炎症和RAGE表达来降低AGE水平。葡萄糖代谢和血糖控制的改善也是其他可能的解释。外周胰岛素抵抗降低可能会减弱AGE的积累。体育锻炼可以分泌更多的抗氧化酶,减少氧化应激。运动可以改善抗氧化和抗炎的内皮功能。运动后,内皮下基质硬度降低,内皮功能改善。在本研究中,讨论了AGEs与运动之间的关系及其对CVD的相互作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
1.10
自引率
0.00%
发文量
10
审稿时长
19 weeks
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