Recent Advances in Zika Virus Vaccine Development

Abstract

Symbiosis Group Figure 1: Three different mechanisms of ADE (Antibody-dependent enhancement): A-receptors on virus particles bound by cross-reactive antibody get conformational change in structure that results in high affinity with the corresponding receptor on the host cell membrane. The corresponding receptor was not able to recognize the viral receptor before this conformational change. BThe cross-reactive antibody binds to viral and host cell membrane receptors at the same time bringing the viral particle near to the host cell. CThe Fc component of the cross-reactive antibody is recognized by the corresponding receptor on host cell membrane being the predominant mechanism of ADE phenomenon. Transmission