Correlación de los valores de vitamina D con los de hormona antimülleriana en mujeres con infertilidad

Abstract

OBJECTIVE: To evaluate the association between serum concentrations of 25-hydroxyvi- tamin D and antimullerian hormone in Mexican patients with infertility. MATERIALS AND METHODS: Retrospective, cross-sectional study of relational analysis of patients who came to consult at the IECH Fertility Center between the months of May 2019 and May 2020. The Kolmogorov-Smirnov normality test was used, with means and standard deviations (SD) for normal values; medians and interquantity ranges (IQR) for non-parametric values. To show differences between the groups the paired t-test and Mann-Whitney test were applied depending, respectively, on the normality of the data and the Spearman correlation coefficient to calculate the dependence between non-parametric variables. GraphPad Prism (v 8) was used, the value of p < 0.05 was considered with statistical significance. RESULTS: A total of 106 files of patients diagnosed with infertility with a mean age of 35 4.97 and a median of 19.90 ng/mL (IQR 57.06) of 25-hydroxyvitamin D were analyzed. Vitamin D deficiency (less than 20 ng/mL) was not associated with antimul- lerian hormone values (p = 0.0525); a difference was found between vitamin D con-Mario centrations for patients younger and older than 35 years (p = 0.0423) and a correlation between vitamin D and antimullerian hormone (Spearman’s rho: -0.210, 95%CI -0.41 to -0.005, p = 0.0495). CONCLUSIONS: 50% of the infertile patients had vitamin D deficiency. Although the mechanism is not properly elucidated, there is a dependence on the values of 25-hy-droxyvitamin D and the antimullerian hormone.