(-)-Menthol-β-cyclodextrin inclusion complex production and characterization

IF 0.7 4区工程技术 Q4 CHEMISTRY, APPLIED

Polish Journal of Chemical Technology Pub Date : 2022-06-01 DOI:10.2478/pjct-2022-0008

Guangyong Zhu, Zuobing Xiao, Rujun Zhou, Junhua Liu, G. Zhu, Xiongjian Zheng

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引用次数: 2

Abstract

Abstract (-)-Menthol has been widely used in clinical medicine, flavor, and fragrance. However, high volatility, short retention time, low solubility in water, and whisker growth of menthol are crucial problems for its application. In this paper, (-)-menthol-β-cyclodextrin inclusion complex was fabricated to solve these problems. The product was characterized by X-ray diffraction, Fourier transform infrared spectroscopy and thermogravimetric analysis. The results showed that menthol was successfully encapsulated in the cavity of β-cyclodextrin. Menthol itself vaporized almost completely at around 120 oC, while the maximum menthol release rate occurred at 267.5 oC after the formation of the inclusion complex. The stability and retention time were improved. The menthol release reaction order, apparent activation energy and the pre-exponential factor were obtained and their values were 0, 142.9 kJ/mol and 1.6 × 1013 respectively. The structure of menthol-β-cyclodextrin inclusion complex was investigated by molecular simulation and the minimum energy, –116.7 kJ/mol, was obtained at –0.8 × 10–10 m.

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（-）-薄荷醇-β-环糊精包合物的制备与表征

摘要（-）薄荷醇在临床医学、香精香料等方面有着广泛的应用。然而，薄荷醇的高挥发性、短停留时间、低水溶性和晶须生长是其应用的关键问题。为了解决这些问题，本文制备了（-）-薄荷醇-β-环糊精包合物。通过X射线衍射、傅立叶变换红外光谱和热重分析对产物进行了表征。结果表明，薄荷醇成功地包封在β-环糊精的空腔中。薄荷醇本身在120℃左右几乎完全蒸发，而最大薄荷醇释放速率发生在包合物形成后的267.5℃。稳定性和保留时间得到改善。得到了薄荷醇的释放反应级数、表观活化能和指数前因子，其值分别为0、142.9 kJ/mol和1.6×1013。通过分子模拟研究了薄荷醇-β-环糊精包合物的结构，在–0.8×10–10m处获得了最小能量–116.7kJ/mol。

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来源期刊

Polish Journal of Chemical Technology CHEMISTRY, APPLIED-ENGINEERING, CHEMICAL

CiteScore

1.70

自引率

10.00%

发文量

审稿时长

4.5 months

期刊介绍： Polish Journal of Chemical Technology is a peer-reviewed, international journal devoted to fundamental and applied chemistry, as well as chemical engineering and biotechnology research. It has a very broad scope but favors interdisciplinary research that bring chemical technology together with other disciplines. All authors receive very fast and comprehensive peer-review. Additionally, every published article is promoted to researchers working in the same field.