Evaluation of the Differences between Normal and Cancerous Prostate Tissue Response to Simple and Vibro-Neural Stimulation

Abstract

Background : Early detection of prostate cancer has significant benefits for its treatment and can increase the survival chance in patients. In recent years, new methods such as shear wave elastography and vibro-elastography, as well as artificial tactile sensing, have been used to detect a mass in the prostate tissue in-vivo and ex-vivo. This paper aims to investigate the difference between normal and malignant prostate tissue reaction to simple and vibro-neural stimulation for prostate tissue mass detection in order to determine neural stimulation intensity, velocity, and frequency to obtain the best result in detecting the type and location of the tumor. Methods : This study has utilized neural stimulation devices in normal and cancerous tissues. The stimulation velocity, probe location, and the frequency of neural stimulation considered as the independent variables. Results : The results show that for superficial masses, although dependent on the probe, the accuracy of detection at the low speed of 5mm/s is 50% higher than other conditions. On the other hand, in deep masses, with increasing mass depth, the accuracy of detection at the medium speed of 8mm/s is 30% higher than the low speed. Finally, the results showed that with increased stimulation frequency, the possibility of tumor detection, and its accuracy increases by 35%. Conclusion : By improving the accuracy of the neural stimulation device, it can apply to detect hard materials such as tumors and malignant tissues.