New composition of tungsten has a broad range of antiviral activity

Q2 Pharmacology, Toxicology and Pharmaceutics

Antiviral Chemistry and Chemotherapy Pub Date : 2022-01-01 DOI:10.1177/20402066221090061

H. Avagyan, A. Mirzoyan, F. Mirzoyan, Roza Izmailyan, Sona Hakobyan, H. Voskanyan, Z. Semerjyan, A. Avetisyan, H. Arzumanyan, E. Karalova, L. Abroyan, L. Hakobyan, N. Bayramyan, N. Gevorgyan, Alexander Karalyan, Z. Karalyan

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引用次数: 0

Abstract

The water-based combination of two inorganic chemical compounds such as sodium tungstate dihydrate-Na2WO4 × 2H2O and Aluminum sulfate octadecahydrate-Al2 (SO4) 3 × 18H2O that we have conditionally named ‘Vomifal’ has a broad antiviral activity in various DNA and RNA viruses, including Human Herpes Virus (HHV), African Swine Fever Virus (ASFV), Vaccinia Virus (VV), Hepatitis C Virus (HCV), Foot and Mouth Disease Virus (FMDV), Influenza A virus (A/Aichi/2/68 (H3N2)). In vitro and In vivo assays in several tissue cultures as well as in laboratory animals, conformed ‘Vomifal’ has a very low toxicity and the antiviral properties partially are due to its ability to induce gamma-IFN. Based on the results obtained, we can assume the presence of at least two mechanisms of the antiviral action of the studied drug. First or early stage - an unknown mechanism, possibly related to the effect on cellular receptors. Second or late stage – main antiviral properties probably associated with an interferonogenic effect.

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新合成的钨具有广泛的抗病毒活性

我们有条件地命名为“Vomifal”的两种无机化合物的水基组合，如二水合钨酸钠- na2wo4 × 2H2O和硫酸铝- al2 (SO4) 3 × 18H2O，对各种DNA和RNA病毒具有广泛的抗病毒活性，包括人类疱疹病毒(HHV)、非洲猪瘟病毒(ASFV)、牛痘病毒(VV)、丙型肝炎病毒(HCV)、口蹄疫病毒(FMDV)、甲型流感病毒(a /爱知/2/68 (H3N2))。在几种组织培养物以及实验动物的体外和体内试验中，一致的' Vomifal '具有非常低的毒性，其抗病毒特性部分是由于其诱导γ - ifn的能力。根据所获得的结果，我们可以假设所研究药物的抗病毒作用存在至少两种机制。初期或早期-机制未知，可能与细胞受体的作用有关。第二阶段或晚期-主要抗病毒特性可能与干扰素产生作用有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Antiviral Chemistry and Chemotherapy Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

5.20

自引率

0.00%

发文量

审稿时长

15 weeks

期刊介绍： Antiviral Chemistry & Chemotherapy publishes the results of original research concerned with the biochemistry, mode of action, chemistry, pharmacology and virology of antiviral compounds. Manuscripts dealing with molecular biology, animal models and vaccines are welcome. The journal also publishes reviews, pointers, short communications and correspondence.