Focusing on the regulation of epigenetic modification on retinal vascular disease

Q4 Medicine

中华眼底病杂志 Pub Date : 2020-03-25 DOI:10.3760/CMA.J.CN511434-20200310-00104

Chen Zhao

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引用次数: 0

Abstract

Epigenetics has been very hot in the research of biomedicine. In addition to genetic factors, the occurrence of a disease is also influenced by environmental factors. Retinal vascular diseases are a type of irreversible blind eye disease, such as age-related macular degeneration and diabetic retinopathy. The retinal vessel changes are the major features of retinal vascular diseases, which are the result of interaction of multiple environmental factors and genes. Epigenetic modification mainly includes DNA methylation, histone modification, and non-coding RNA regulation. Epigenetic mechanisms mediate the effects of environmental factors on genes related to retinal vascular diseases, and affect the eventual development of the diseases. Therefore, ophthalmologists should keep eyes close on the role of epigenetics in retinal vascular diseases, track the progress of epigenetic methods in the treatment of retinal vascular diseases, and pay attention to the application prospects of epigenetics. Finding the epigenetic regulators of these diseases can not only deepen the understanding of the pathological mechanism of these diseases, but also provide new ideas for the diagnosis and treatment of these diseases. Key words: Epigenomics; Epigenesis, genetic; Diabetic retinopathy/genetics; Wet macular degeneration/genetics; Editorial

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重点研究表观遗传修饰在视网膜血管疾病中的调控作用

表观遗传学一直是生物医学研究的热点。除了遗传因素外，疾病的发生还受环境因素的影响。视网膜血管疾病是一种不可逆的盲眼病，如老年性黄斑变性、糖尿病性视网膜病变等。视网膜血管改变是视网膜血管性疾病的主要特征，是多种环境因素和基因相互作用的结果。表观遗传修饰主要包括DNA甲基化、组蛋白修饰和非编码RNA调控。表观遗传机制介导环境因素对视网膜血管疾病相关基因的影响，并影响疾病的最终发展。因此，眼科医生应密切关注表观遗传学在视网膜血管疾病中的作用，跟踪表观遗传学方法在视网膜血管疾病治疗中的进展，关注表观遗传学的应用前景。发现这些疾病的表观遗传调控因子不仅可以加深对这些疾病病理机制的认识，而且可以为这些疾病的诊断和治疗提供新的思路。关键词:表观基因组学;渐成基因;糖尿病性视网膜病变/遗传学;湿性黄斑变性/遗传学;编辑

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来源期刊

中华眼底病杂志 Medicine-Ophthalmology

CiteScore

0.40

自引率

0.00%

发文量

5383

期刊介绍： Chinese Journal of Ocular Fundus Diseases is the only scientific journal in my country that focuses on reporting fundus diseases. Its purpose is to combine clinical and basic research, and to give equal importance to improvement and popularization. It comprehensively reflects the leading clinical and basic research results of fundus disease disciplines in my country; cultivates professional talents in fundus disease, promotes the development of fundus disease disciplines in my country; and promotes academic exchanges on fundus disease at home and abroad. The coverage includes clinical and basic research results of posterior segment diseases such as retina, uveal tract, vitreous body, visual pathway, and internal eye diseases related to systemic diseases. The readers are medical workers and researchers related to clinical and basic research of fundus diseases. According to the journal retrieval report of the Chinese Institute of Scientific and Technological Information, the comprehensive ranking impact factor and total citation frequency of the Chinese Journal of Ocular Fundus Diseases have been among the best in the disciplines of ophthalmology, otolaryngology, and ophthalmology in my country for many years. The papers published have been included in many important databases at home and abroad, such as Scopus, Peking University Core, and China Science Citation Database (CSCD).