Stilbenes at Low Micromolar Concentrations Mitigate the NO, TNF-α, IL-1β and ROS Production in LPS-Stimulated Murine Macrophages

IF 0.9 Q4 CHEMISTRY, MEDICINAL

Journal of Biologically Active Products from Nature Pub Date : 2021-05-04 DOI:10.1080/22311866.2021.1923571

Iris Aja-Perez, S. Krisa, R. Hornedo-Ortega, M. Ruiz-Larrea, J. Ruiz-Sanz, T. Richard, A. Courtois

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引用次数: 3

Abstract

Abstract Stilbenes, of which resveratrol is the most studied, were described as antioxidant and anti-inflammatory molecules. Presumably, other stilbenes have similar biological properties, but the evidence is poorly documented. Therefore, 20 stilbenes from resveratrol monomers to tetramers were screened as anti-inflammatory and antioxidant agents in a cellular model of LPS-stimulated murine macrophages. Piceatannol (monomer), ϵ-viniferin and δ-viniferin (dimers), hopeaphenol and isohopeaphenol (tetramers) were the most powerful compounds that inhibited NO and ROS generation upon LPS exposure. Among these compounds, hopeaphenol (5-10 µM) showed the highest efficiency. Nevertheless, ϵ-viniferin was the most powerful to inhibit TNF-α release whereas isohopeaphenol was the greatest to reduce IL-1β upon LPS stimulation. Thus, this work provided evidence that the chemical structure of stilbenes is highly relevant to the behavior of their activities. These results will allow the selection of potential bioactive stilbenes to develop further studies to elucidate their molecular mechanism of action. Graphical abstract

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低微摩尔浓度二苯乙烯降低lps刺激小鼠巨噬细胞NO、TNF-α、IL-1β和ROS的产生

摘要白藜芦醇是研究最多的二苯乙烯类化合物，被描述为抗氧化和抗炎分子。据推测，其他二苯乙烯具有类似的生物特性，但证据很少。因此，在LPS刺激的小鼠巨噬细胞的细胞模型中，从白藜芦醇单体到四聚体的20个二苯乙烯被筛选为抗炎和抗氧化剂。Piceatannol（单体）、ε-长春花苷和δ-长春花素（二聚体）、霍普酚和异霍普酚（四聚体）是LPS暴露后抑制NO和ROS产生的最有效的化合物。在这些化合物中，霍普酚（5-10µM）显示出最高的效率。然而，在LPS刺激下，长春花苷对TNF-α释放的抑制作用最强，而异Hopephenol对IL-1β的抑制作用最大。因此，这项工作提供了证据，证明二苯乙烯的化学结构与它们的活性行为高度相关。这些结果将有助于选择潜在的生物活性二苯乙烯进行进一步的研究，以阐明其分子作用机制。图形摘要

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来源期刊

Journal of Biologically Active Products from Nature Agricultural and Biological Sciences-Agricultural and Biological Sciences (miscellaneous)

CiteScore

2.10

自引率

0.00%

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