A Rare Case of Osseous Metaplasia in Canine Leiomyoma and Plasticity of Smooth Muscle Cell

IF 0.7 4区农林科学 Q3 VETERINARY SCIENCES

Acta Veterinaria-Beograd Pub Date : 2022-06-01 DOI:10.2478/acve-2022-0021

Eun-Joo Lee, K. Jeong

{"title":"A Rare Case of Osseous Metaplasia in Canine Leiomyoma and Plasticity of Smooth Muscle Cell","authors":"Eun-Joo Lee, K. Jeong","doi":"10.2478/acve-2022-0021","DOIUrl":null,"url":null,"abstract":"Abstract Metaplasia is a transformation of one mature cell type to other kinds of mature cells. Metaplasia is hardly detected in benign tumors, whereas it is frequently observed in malignant tumors. In this study, we report the first case of osseous metaplasia in canine leiomyoma. The region of osseous metaplasia was highly eosinophilic and had various sizes of distinct lacunae. The osseoid material was confirmed by Von Kossa staining. Except for the osseous metaplasia, the mass presented typical features of leiomyoma without any histopathological features of malignancy. The characteristics of malignant tumors, including pleomorphism, mitotic figures, and lymphatic metastasis were not identified and the mass was proven to be a benign tumor. The osseous metaplasia in leiomyoma without dysplastic changes might be due to plasticity which is a unique feature of smooth muscle cells, whether the tumor is malignant or not. This case suggests the possible occurrence of osseous metaplasia in leiomyoma, which has been overlooked due to the lack of reports. Also, it is recommended to pay attention to making a diagnosis of smooth muscle tumor with metaplasia so as not to be confused with leiomyosarcoma and leiomyoma variants.","PeriodicalId":55559,"journal":{"name":"Acta Veterinaria-Beograd","volume":null,"pages":null},"PeriodicalIF":0.7000,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta Veterinaria-Beograd","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.2478/acve-2022-0021","RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}

引用次数: 0

Abstract

Abstract Metaplasia is a transformation of one mature cell type to other kinds of mature cells. Metaplasia is hardly detected in benign tumors, whereas it is frequently observed in malignant tumors. In this study, we report the first case of osseous metaplasia in canine leiomyoma. The region of osseous metaplasia was highly eosinophilic and had various sizes of distinct lacunae. The osseoid material was confirmed by Von Kossa staining. Except for the osseous metaplasia, the mass presented typical features of leiomyoma without any histopathological features of malignancy. The characteristics of malignant tumors, including pleomorphism, mitotic figures, and lymphatic metastasis were not identified and the mass was proven to be a benign tumor. The osseous metaplasia in leiomyoma without dysplastic changes might be due to plasticity which is a unique feature of smooth muscle cells, whether the tumor is malignant or not. This case suggests the possible occurrence of osseous metaplasia in leiomyoma, which has been overlooked due to the lack of reports. Also, it is recommended to pay attention to making a diagnosis of smooth muscle tumor with metaplasia so as not to be confused with leiomyosarcoma and leiomyoma variants.

查看原文本刊更多论文

犬平滑肌瘤骨化生1例及平滑肌细胞可塑性

摘要化生是一种成熟细胞类型向其他类型成熟细胞的转化。在良性肿瘤中几乎没有发现发育异常，而在恶性肿瘤中经常观察到。在这项研究中，我们报告了第一例犬平滑肌瘤的骨化生。骨化生区域高度嗜酸性，有不同大小的明显腔隙。Von-Kossa染色证实了骨样物质。除骨化生外，肿块表现为典型的平滑肌瘤特征，无任何恶性组织病理学特征。恶性肿瘤的特征，包括多形性、有丝分裂和淋巴转移，均未确定，肿块被证明是良性肿瘤。平滑肌瘤的骨化生没有发育异常变化，这可能是由于可塑性，这是平滑肌细胞的一个独特特征，无论肿瘤是否恶性。该病例提示平滑肌瘤可能发生骨化生，但由于缺乏报道而被忽视。此外，建议注意对伴有化生的平滑肌肿瘤进行诊断，以免与平滑肌肉瘤和平滑肌瘤变体混淆。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Acta Veterinaria-Beograd 农林科学-兽医学

CiteScore

1.30

自引率

16.70%

发文量

审稿时长

18-36 weeks

期刊介绍： The Acta Veterinaria is an open access, peer-reviewed scientific journal of the Faculty of Veterinary Medicine, University of Belgrade, Serbia, dedicated to the publication of original research articles, invited review articles, and to limited extent methodology articles and case reports. The journal considers articles on all aspects of veterinary science and medicine, including the diagnosis, prevention and treatment of medical conditions of domestic, companion, farm and wild animals, as well as the biomedical processes that underlie their health.