Design and Fabrication of In-house Nozzle System to Extrude Multi-Hydrogels for 3D Bioprinting Process

IF 2.4 3区 工程技术 Q3 ENGINEERING, MANUFACTURING
Connor Quigley, Rokeya Sarah, Warren Hurd, Scott Clark, M. Habib
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引用次数: 0

Abstract

The field of 3D bio-printing is rapidly expanding as researchers strive to create functional tissues for medical and pharmaceutical purposes. The ability to print multiple materials, each containing various living cells, brings us closer to achieving tissue regeneration. In a previous study, we designed a Y-shaped nozzle connector system that allowed for continuous deposition of multiple materials. This system was made of plastic and had a fixed switching angle, rendering it suitable for a single use. In this paper, we present the updated version of our nozzle system, which includes a range of angles (30°, 45°, 60°, and 90° degrees) between the two materials. We used stainless steel as the fabrication material and recorded the overall material switching time, comparing the effects of the various angles. Our previously developed hybrid hydrogel, which comprised 4% Alginate and 4% Carboxymethyl Cellulose (CMC), was used as a test material to flow through the nozzle system. The in-house fabricated nozzle connectors are reusable, sterile, and easy to clean, ensuring a smooth material transition and flow.
生物3D打印过程中多水凝胶挤出内部喷嘴系统的设计与制造
随着研究人员努力为医疗和制药目的创造功能组织,3D生物打印领域正在迅速扩大。打印多种材料的能力,每种材料都包含各种活细胞,使我们更接近实现组织再生。在之前的研究中,我们设计了一个y形喷嘴连接系统,可以连续沉积多种材料。该系统由塑料制成,具有固定的开关角度,适合一次性使用。在本文中,我们介绍了我们的喷嘴系统的更新版本,其中包括两种材料之间的角度范围(30°,45°,60°和90°)。我们使用不锈钢作为制造材料,记录整体材料切换时间,比较不同角度的效果。我们之前开发的混合水凝胶,由4%海藻酸盐和4%羧甲基纤维素(CMC)组成,用作流过喷嘴系统的测试材料。内部制造的喷嘴连接器可重复使用,无菌,易于清洁,确保顺利的材料过渡和流动。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
6.80
自引率
20.00%
发文量
126
审稿时长
12 months
期刊介绍: Areas of interest including, but not limited to: Additive manufacturing; Advanced materials and processing; Assembly; Biomedical manufacturing; Bulk deformation processes (e.g., extrusion, forging, wire drawing, etc.); CAD/CAM/CAE; Computer-integrated manufacturing; Control and automation; Cyber-physical systems in manufacturing; Data science-enhanced manufacturing; Design for manufacturing; Electrical and electrochemical machining; Grinding and abrasive processes; Injection molding and other polymer fabrication processes; Inspection and quality control; Laser processes; Machine tool dynamics; Machining processes; Materials handling; Metrology; Micro- and nano-machining and processing; Modeling and simulation; Nontraditional manufacturing processes; Plant engineering and maintenance; Powder processing; Precision and ultra-precision machining; Process engineering; Process planning; Production systems optimization; Rapid prototyping and solid freeform fabrication; Robotics and flexible tooling; Sensing, monitoring, and diagnostics; Sheet and tube metal forming; Sustainable manufacturing; Tribology in manufacturing; Welding and joining
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