Association of Chronic Kidney Disease and Coronary Heart Disease in A Series of Saudi Patients

Cardiology research and cardiovascular medicine Pub Date : 2023-06-02 DOI:10.29011/2575-7083.100093

A. H. Alghamdi, A. Alaryni, M. Alshammri, S. Hadi, Hussain Gadelkarim, Prof. Hussain Gadelkarim, Ahmed

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Abstract

Objectives: this study aimed to assess the association between CKD and coronary heart disease (CHD) in a series of Saudi patients. Methods: This study investigated 2700 Saudi volunteers during a cross-sectional survey conducted in Hai’l region. Participants were included based randomly regardless of age or gender. CKD stage was determined according to GFR estimation using creatinine level, age, and sex. Results: The risk of CHD associated with CKD, the relative risk (RR), and the 95% confidence interval was RR (95%CI) = 8.5045(4.5035 to 16.0602), P < 0.0001. The risk of CHD among patients above 41 years was statistically significant, with the RR (95%CI) = 5.6978 (2.3849 to 13.6126), P = 0.0001. The risk of CHD associated with FHRD was the RR (95%CI) = 5.2567 (2.5146 to 10.9891), P = 0.0001. Conclusion: There is a statistically significant association between CKD and CHD in a population with shared risk factors such as hypertension, diabetes, and obesity. A statistically significant positive association between CKD & CHD and Saudi rural inhabitants, family history of renal disease, and ex-smoking.

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沙特一系列患者慢性肾脏疾病与冠心病的相关性

目的:本研究旨在评估一系列沙特患者CKD与冠心病(CHD)之间的关系。方法:本研究在海伊尔地区对2700名沙特志愿者进行了横断面调查。参与者是随机纳入的，无论年龄或性别。CKD分期是根据GFR估计的肌酐水平、年龄和性别来确定的。结果:冠心病合并CKD的危险度，相对危险度(RR)， 95%可信区间RR (95% ci) = 8.5045(4.5035 ~ 16.0602)， P < 0.0001。41岁以上患者发生冠心病的风险有统计学意义，RR (95%CI) = 5.6978 (2.3849 ~ 13.6126)， P = 0.0001。CHD与FHRD相关的风险RR (95%CI) = 5.2567 (2.5146 ~ 10.9891)， P = 0.0001。结论:在具有高血压、糖尿病和肥胖等共同危险因素的人群中，CKD和冠心病之间存在统计学意义上的相关性。CKD和CHD与沙特农村居民、肾脏疾病家族史和戒烟者之间有统计学意义的正相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Cardiology research and cardiovascular medicine

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