The wing imaginal disc

IF 3.3 3区生物学

Genetics Pub Date : 2022-02-21 DOI:10.1093/genetics/iyac020

B. Tripathi, K. Irvine

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引用次数: 19

Abstract

Abstract The Drosophila wing imaginal disc is a tissue of undifferentiated cells that are precursors of the wing and most of the notum of the adult fly. The wing disc first forms during embryogenesis from a cluster of ∼30 cells located in the second thoracic segment, which invaginate to form a sac-like structure. They undergo extensive proliferation during larval stages to form a mature larval wing disc of ∼35,000 cells. During this time, distinct cell fates are assigned to different regions, and the wing disc develops a complex morphology. Finally, during pupal stages the wing disc undergoes morphogenetic processes and then differentiates to form the adult wing and notum. While the bulk of the wing disc comprises epithelial cells, it also includes neurons and glia, and is associated with tracheal cells and muscle precursor cells. The relative simplicity and accessibility of the wing disc, combined with the wealth of genetic tools available in Drosophila, have combined to make it a premier system for identifying genes and deciphering systems that play crucial roles in animal development. Studies in wing imaginal discs have made key contributions to many areas of biology, including tissue patterning, signal transduction, growth control, regeneration, planar cell polarity, morphogenesis, and tissue mechanics.

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翅膀想象盘

摘要果蝇的翅膀想象盘是一种未分化细胞的组织，这些细胞是成年苍蝇翅膀和大部分notum的前体。翼盘在胚胎发生过程中首先由位于第二胸段的一簇～30个细胞形成，这些细胞内陷形成囊状结构。它们在幼虫阶段经历广泛的增殖，形成约35000个细胞的成熟幼虫翼盘。在这段时间里，不同的细胞命运被分配到不同的区域，翼盘形成了复杂的形态。最后，在蛹期，翅盘经历形态发生过程，然后分化形成成虫的翅膀和绒毛。虽然翼盘的大部分包括上皮细胞，但它也包括神经元和神经胶质，并与气管细胞和肌肉前体细胞有关。翼盘相对简单易用，再加上果蝇丰富的遗传工具，使其成为识别基因和破译在动物发育中发挥关键作用的系统的首要系统。对翅膀想象盘的研究在生物学的许多领域做出了关键贡献，包括组织模式、信号转导、生长控制、再生、平面细胞极性、形态发生和组织力学。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Genetics 生物-遗传学

CiteScore

6.20

自引率

6.10%

发文量

177

期刊介绍： GENETICS is published by the Genetics Society of America, a scholarly society that seeks to deepen our understanding of the living world by advancing our understanding of genetics. Since 1916, GENETICS has published high-quality, original research presenting novel findings bearing on genetics and genomics. The journal publishes empirical studies of organisms ranging from microbes to humans, as well as theoretical work. While it has an illustrious history, GENETICS has changed along with the communities it serves: it is not your mentor''s journal. The editors make decisions quickly – in around 30 days – without sacrificing the excellence and scholarship for which the journal has long been known. GENETICS is a peer reviewed, peer-edited journal, with an international reach and increasing visibility and impact. All editorial decisions are made through collaboration of at least two editors who are practicing scientists. GENETICS is constantly innovating: expanded types of content include Reviews, Commentary (current issues of interest to geneticists), Perspectives (historical), Primers (to introduce primary literature into the classroom), Toolbox Reviews, plus YeastBook, FlyBook, and WormBook (coming spring 2016). For particularly time-sensitive results, we publish Communications. As part of our mission to serve our communities, we''ve published thematic collections, including Genomic Selection, Multiparental Populations, Mouse Collaborative Cross, and the Genetics of Sex.