Hepatitis B Infection in Pregnancy-Experience at a Tertiary Care Centre of North India

Journal of hematology research Pub Date : 2017-02-27 DOI:10.12974/2312-5411.2017.04.5

V. Malhotra, P. Malhotra, Vandana Bhuriya, I. Pahuja, S. Nanda, M. Chauhan, N. Sangwan

{"title":"Hepatitis B Infection in Pregnancy-Experience at a Tertiary Care Centre of North India","authors":"V. Malhotra, P. Malhotra, Vandana Bhuriya, I. Pahuja, S. Nanda, M. Chauhan, N. Sangwan","doi":"10.12974/2312-5411.2017.04.5","DOIUrl":null,"url":null,"abstract":"Objectives: To investigate the Seroprevalence of hepatitis B surface antigen in pregnant women and managing chronic HBV infection in pregnant women for preventing mother to child transmission.\nMethods: Fifteen thousand pregnant women were evaluated using history, examination and test for serum HbsAg and who were found to be HbsAg positive underwent liver function tests, HbeAg and HBV DNA analysis by Polymerase Chain Reaction (PCR).\nResults: out of fifteen thousand (15000) women, 52 women tested positive for HbsAg. Of these, 8(15.38%) presented with acute hepatitis and 44(84.6%) were asymptomatic carriers. The highest HbsAg positivity was seen in age group of 20-25 years and maximum women were multiparous (67.23%). Assessment of risk factors revealed history of tattooing in 22 women (42.3%). Out of 52 women, 12 patients tested positive for HbeAg and their DNA tires were more than one Lakh copies/ml. Forty six women(88.4%) delivered vaginally and rest 6(11.5%) underwent cesarean section which was mainly done for obstetric indications. All the babies born received immunoglobulin and first dose of HBV vaccine within 12 hours of birth.\nConclusion: Seroprevalence of HbsAg in antenatal women was found to be 0.34%. ","PeriodicalId":91541,"journal":{"name":"Journal of hematology research","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2017-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of hematology research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.12974/2312-5411.2017.04.5","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 1

Abstract

Objectives: To investigate the Seroprevalence of hepatitis B surface antigen in pregnant women and managing chronic HBV infection in pregnant women for preventing mother to child transmission. Methods: Fifteen thousand pregnant women were evaluated using history, examination and test for serum HbsAg and who were found to be HbsAg positive underwent liver function tests, HbeAg and HBV DNA analysis by Polymerase Chain Reaction (PCR). Results: out of fifteen thousand (15000) women, 52 women tested positive for HbsAg. Of these, 8(15.38%) presented with acute hepatitis and 44(84.6%) were asymptomatic carriers. The highest HbsAg positivity was seen in age group of 20-25 years and maximum women were multiparous (67.23%). Assessment of risk factors revealed history of tattooing in 22 women (42.3%). Out of 52 women, 12 patients tested positive for HbeAg and their DNA tires were more than one Lakh copies/ml. Forty six women(88.4%) delivered vaginally and rest 6(11.5%) underwent cesarean section which was mainly done for obstetric indications. All the babies born received immunoglobulin and first dose of HBV vaccine within 12 hours of birth. Conclusion: Seroprevalence of HbsAg in antenatal women was found to be 0.34%.

查看原文本刊更多论文

妊娠期乙型肝炎感染——印度北部三级保健中心的经验

目的：了解孕妇乙型肝炎表面抗原的血清流行情况，并管理孕妇慢性乙型肝炎病毒感染，预防母婴传播。方法：对1万5千名孕妇进行病史、检查和血清HbsAg检测，对发现HbsAg阳性的孕妇进行肝功能检测、HbeAg和HBVDNA聚合酶链式反应（PCR）分析。其中8例（15.38%）为急性肝炎，44例（84.6%）为无症状携带者。HbsAg阳性率最高的是20-25岁年龄组，多胎女性最多（67.23%）。风险因素评估显示22名女性（42.3%）有纹身史。在52名女性中，12名患者的HbeAg检测呈阳性，她们的DNA轮胎超过10万拷贝/ml。46名妇女（88.4%）通过阴道分娩，其余6名妇女（11.5%）接受了剖宫产手术，这主要是为了适应产科需要。所有出生的婴儿都在出生后12小时内接种了免疫球蛋白和第一剂乙肝疫苗。结论：产前妇女血清HbsAg阳性率为0.34%。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of hematology research

自引率

0.00%

发文量