Expression and significance of X chromosome linked inhibitor of apoptosis protein, high mobility group box-1 protein and Vimentin in gastric cancer

中华实验外科杂志 Pub Date : 2020-01-08 DOI:10.3760/CMA.J.ISSN.1001-9030.2020.01.041

Yong Xu, Rongchao Ying

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Abstract

Objective To explore the expression and significance of X chromosome linked inhibitor of apoptosis protein (XIAP), high mobility group box-1 protein (HMGB1) and Vimentin in gastric cancer. Methods The expression levels of XIAP, HMGB1 and Vimentin in 84 cases of gastric cancer and adjacent normal tissues were detected by immunohistochemical in June 2016 to January 2019 in Hangzhou Dajiangdong Hospital, and the relationship between the expression of XIAP, HMGB1 and Vimentin and clinicopathological parameters was analyzed. Results The positive expression rate of XIAP in gastric cancer (65.48%, 55/84) was higher than that in adjacent normal tissues (17.86%, 15/84, χ2=50.837, P<0.05). The positive expression rate of HMGB1 in gastric cancer tissues (75.00%, 63/84) was higher than that in adjacent normal tissues (9.52%, 8/84, , χ2=73.791, P<0.05). The positive expression rate of Vimentin in gastric cancer tissues (70.23%, 59/84) was higher than that in adjacent normal tissues (20.24%, 17/84, χ2=42.384, P<0.05). The positive rate of XIAP, HMGB1 and Vimentin in stage Ⅲ-Ⅳ of gastric cancer was significantly higher than that in stage Ⅰ-Ⅱ (χ2=12.574, 9.821, P<0.05). The positive expression rate of XIAP, HMGB1 and Vimentin in patients with lymph node metastasis was significantly higher than that in patients without lymph node metastasis (χ2=23.290, 25.337, P<0.05). The positive rate of XIAP, HMGB1 and Vimentin in gastric cancer tissues were not correlated with age, sex and degree of differentiation. There was positive correlation between XIAP and HMGB1 (r=0.597, P<0.01), between XIAP and Vimentin (r=0.621, P<0.01), and between HMGB1 and Vimentin (r=0.634, P<0.01). Conclusion XIAP, HMGB1 and Vimentin were highly expressed in gastric cancer tissues, which could be used as predictors of the occurrence and malignancy of gastric cancer. Key words: X chromosome linked inhibitor of apoptosis protein; High mobility group box-1 protein; Vimentin; Gastric cancer

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X染色体连锁凋亡抑制蛋白、高迁移率组box-1蛋白和Vimentin在胃癌组织中的表达及意义

目的探讨X染色体连锁凋亡抑制蛋白(XIAP)、高迁移率组盒-1蛋白(HMGB1)和Vimentin在胃癌组织中的表达及意义。方法采用免疫组化方法检测2016年6月至2019年1月杭州大江东医院84例胃癌及癌旁正常组织中XIAP、HMGB1和Vimentin的表达水平，分析XIAP、HMGB1和Vimentin的表达与临床病理参数的关系。结果XIAP在胃癌组织中的阳性表达率(65.48%，55/84)高于癌旁正常组织(17.86%，15/84，χ2=50.837, P<0.05)。HMGB1在胃癌组织中的阳性表达率(75.00%，63/84)高于癌旁正常组织(9.52%，8/84)，χ2=73.791, P<0.05)。Vimentin在胃癌组织中的阳性表达率(70.23%，59/84)高于癌旁正常组织(20.24%，17/84，χ2=42.384, P<0.05)。XIAP、HMGB1、Vimentin在Ⅲ~Ⅳ期胃癌的阳性率显著高于Ⅰ~Ⅱ期(χ2=12.574、9.821,P<0.05)。XIAP、HMGB1、Vimentin在淋巴结转移患者中的阳性表达率显著高于无淋巴结转移患者(χ2=23.290、25.337,P<0.05)。胃癌组织中XIAP、HMGB1、Vimentin的阳性率与年龄、性别、分化程度无关。XIAP与HMGB1 (r=0.597, P<0.01)、XIAP与Vimentin (r=0.621, P<0.01)、HMGB1与Vimentin (r=0.634, P<0.01)呈正相关。结论XIAP、HMGB1和Vimentin在胃癌组织中高表达，可作为胃癌发生及恶性程度的预测因子。关键词:X染色体连锁凋亡抑制蛋白;高迁移率组box-1蛋白;波形蛋白;胃癌

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中华实验外科杂志

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