Antagonistic effect of platelet-rich plasma on photo-aged skin in rat

中华医学美学美容杂志 Pub Date : 2018-12-15 DOI:10.3760/CMA.J.ISSN.1671-0290.2018.06.019

Wenbo Wu, Minliang Chen, Yanqiu Wu

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Abstract

Objective To observe the effect of platelet-rich plasma (PRP) on photoaging skin of rat. Methods F344 rats were used as model animals and skin photoaging model was established by UV irradiation. The model animals were divided into 5 groups: group A was injected with activated PRP (A-PRP); group B was injected with inactive PRP (N-PRP); group C was injected with normal saline; group D was irradiated only with UV; Four weeks after the injection, the appearance and histological characteristics of the rat＇s skin were evaluated. Results Compared with group C and group D, the wrinkles and skin color in group A and group B were significantly improved. Histological observation showed that the histological features of group A and group B were significantly better than that of group C and D (P 0.05). The thickness of dermis in group E was significantly higher than that in group C (P<0.01). Conclusions Injection of PRP can improve the appearance and histological features of photo-aged skin in rats. A-PRP is better than N-PRP. Key words: Platelet-rich plasma; Light; Cell aging; Skin; Rats; Photoageing

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富血小板血浆对大鼠光老化皮肤的拮抗作用

目的观察富血小板血浆(PRP)对大鼠光老化皮肤的影响。方法以F344大鼠为模型动物，采用紫外线照射法建立皮肤光老化模型。将模型动物分为5组:A组注射活化的PRP (A-PRP);B组注射无活性PRP (N-PRP);C组注射生理盐水;D组仅紫外线照射;注射后4周，观察大鼠皮肤外观及组织学特征。结果与C、D组比较，A、B组患者皱纹、肤色均有明显改善。组织学观察显示，A、B组患者的组织学特征明显优于C、D组(P < 0.05)。E组真皮层厚度极显著高于C组(P<0.01)。结论注射PRP可改善大鼠光老化皮肤的外观和组织学特征。A-PRP优于N-PRP。关键词:富血小板血浆;淡定;细胞老化;皮肤;大鼠;光老化

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来源期刊

中华医学美学美容杂志

自引率

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发文量

4641

期刊介绍： "Chinese Journal of Medical Aesthetics and Cosmetology" is a high-end academic journal focusing on the basic theoretical research and clinical application of medical aesthetics and cosmetology. In March 2002, it was included in the statistical source journals of Chinese scientific and technological papers of the Ministry of Science and Technology, and has been included in the full-text retrieval system of "China Journal Network", "Chinese Academic Journals (CD-ROM Edition)" and "China Academic Journals Comprehensive Evaluation Database". Publishes research and applications in cosmetic surgery, cosmetic dermatology, cosmetic dentistry, cosmetic internal medicine, physical cosmetology, drug cosmetology, traditional Chinese medicine cosmetology and beauty care. Columns include: clinical treatises, experimental research, medical aesthetics, experience summaries, case reports, technological innovations, reviews, lectures, etc.