A Case of Recurrent Anti-MOG-Associated Cerebral Cortical Encephalitis Mimicking Viral Encephalitis and Hemiplegic Migraine

Abstract

Myelin oligodendrocyte glycoprotein (MOG) is an essential component of oligodendrocyte sur-face membranes [1]. Numerous studies have im-plicated MOG in immune-mediated demyelinating diseases, including acute disseminated en-cephalomyelitis, optic neuritis, and transverse myelitis [2]. However, MOG antibody-associated diseases are not limited to demyelinating syndromes. Cerebral cortical encephalitis (CCE), first described by Ogawa et al. [2] in 2017, is a newly identified phenotype of MOG antibody-associated disease. Common symptoms of anti-MOG-associated CCE include seizures, headache, encephalitic features, and cortical symptoms, such as paresis [2]. Unilateral cortical hyperintensities