Supervisory system for automated simulated moving bed (SMB) liquid chromatography (LC)

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2022-09-29 DOI:10.1080/10739149.2022.2128371

R. C. de Holanda, F. C. Cunha, A. Secchi, A. G. Barreto

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引用次数: 0

Abstract

Abstract Praziquantel (PZQ) is a racemic mixture prescribed for Schistosomiasis disease treatment. However, only the enantiomer (R)-PZQ presents demonstrated efficiency against infirmity; the (S)-PZQ causes sickness and vomiting due to its bitter taste. The simulated moving bed chromatography system (SMB) is a well-established separation process applied in many branches of the chemical industry from drug purification stages to food processing systems. In order to implement and operate an SMB for the PZQ separation, allowing the production of medication with proven efficiency and without side effects, a LabVIEW supervisory system was developed. The automated software remotely controlled all equipment in the operational unit, such as automatic pumps, multi-position valves for flow rate alignments, and a chiral detector. Two experiments were conducted to characterize the system’s operational properties and efficiency. The first set of results demonstrated that the data acquisition programming retrieved information constantly, evidencing a direct correlation between the internal liquid pressure and the valve system position, with mean pressure values of approximately 50 bar. The second set of results demonstrated the SMB efficiency, with the raffinate stream producing (R)-PZQ of 100% purity.

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自动模拟移动床(SMB)液相色谱(LC)监控系统

摘要吡喹酮（PZQ）是治疗血吸虫病的外消旋混合物。然而，只有对映体（R）-PZQ表现出对抗衰弱的有效性；（S）-PZQ由于其苦味而引起恶心和呕吐。模拟移动床色谱系统（SMB）是一种成熟的分离工艺，应用于从药物纯化阶段到食品加工系统的化学工业的许多分支。为了实现和操作用于PZQ分离的SMB，使药物生产具有经验证的效率和无副作用，开发了LabVIEW监控系统。自动化软件远程控制操作单元中的所有设备，如自动泵、用于流量校准的多位置阀和手性检测器。进行了两个实验来表征该系统的操作特性和效率。第一组结果表明，数据采集程序不断检索信息，证明内部液体压力和阀门系统位置之间存在直接相关性，平均压力值约为50 酒吧第二组结果证明了SMB效率，萃余液流产生100%纯度的（R）-PZQ。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.