Supervisory system for automated simulated moving bed (SMB) liquid chromatography (LC)

IF 1.3 4区工程技术 Q4 CHEMISTRY, ANALYTICAL

Instrumentation Science & Technology Pub Date : 2022-09-29 DOI:10.1080/10739149.2022.2128371

R. C. de Holanda, F. C. Cunha, A. Secchi, A. G. Barreto

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引用次数: 0

Abstract

Abstract Praziquantel (PZQ) is a racemic mixture prescribed for Schistosomiasis disease treatment. However, only the enantiomer (R)-PZQ presents demonstrated efficiency against infirmity; the (S)-PZQ causes sickness and vomiting due to its bitter taste. The simulated moving bed chromatography system (SMB) is a well-established separation process applied in many branches of the chemical industry from drug purification stages to food processing systems. In order to implement and operate an SMB for the PZQ separation, allowing the production of medication with proven efficiency and without side effects, a LabVIEW supervisory system was developed. The automated software remotely controlled all equipment in the operational unit, such as automatic pumps, multi-position valves for flow rate alignments, and a chiral detector. Two experiments were conducted to characterize the system’s operational properties and efficiency. The first set of results demonstrated that the data acquisition programming retrieved information constantly, evidencing a direct correlation between the internal liquid pressure and the valve system position, with mean pressure values of approximately 50 bar. The second set of results demonstrated the SMB efficiency, with the raffinate stream producing (R)-PZQ of 100% purity.

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自动模拟移动床(SMB)液相色谱(LC)监控系统

摘要吡喹酮（PZQ）是治疗血吸虫病的外消旋混合物。然而，只有对映体（R）-PZQ表现出对抗衰弱的有效性；（S）-PZQ由于其苦味而引起恶心和呕吐。模拟移动床色谱系统（SMB）是一种成熟的分离工艺，应用于从药物纯化阶段到食品加工系统的化学工业的许多分支。为了实现和操作用于PZQ分离的SMB，使药物生产具有经验证的效率和无副作用，开发了LabVIEW监控系统。自动化软件远程控制操作单元中的所有设备，如自动泵、用于流量校准的多位置阀和手性检测器。进行了两个实验来表征该系统的操作特性和效率。第一组结果表明，数据采集程序不断检索信息，证明内部液体压力和阀门系统位置之间存在直接相关性，平均压力值约为50 酒吧第二组结果证明了SMB效率，萃余液流产生100%纯度的（R）-PZQ。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Instrumentation Science & Technology 工程技术-分析化学

CiteScore

3.50

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Instrumentation Science & Technology is an internationally acclaimed forum for fast publication of critical, peer reviewed manuscripts dealing with innovative instrument design and applications in chemistry, physics biotechnology and environmental science. Particular attention is given to state-of-the-art developments and their rapid communication to the scientific community. Emphasis is on modern instrumental concepts, though not exclusively, including detectors, sensors, data acquisition and processing, instrument control, chromatography, electrochemistry, spectroscopy of all types, electrophoresis, radiometry, relaxation methods, thermal analysis, physical property measurements, surface physics, membrane technology, microcomputer design, chip-based processes, and more. Readership includes everyone who uses instrumental techniques to conduct their research and development. They are chemists (organic, inorganic, physical, analytical, nuclear, quality control) biochemists, biotechnologists, engineers, and physicists in all of the instrumental disciplines mentioned above, in both the laboratory and chemical production environments. The journal is an important resource of instrument design and applications data.