SYNTHESIS, MOLECULAR DOCKING AND ANTIMICROBIAL ACTIVITIES 2-(1-ALLYL-1H-TETRAZOL-5-YLSULFANYL)-N-(ARYL)ACETAMIDES

Abstract

We reported an effective synthesis, molecular docking and antimicrobial properties of novel 2-(1-allyl-1 H -tetrazol-5-ylsulfanyl)-N-arylacetamides. The molecular docking studies were performed for all the synthesized compounds against lanosterol 14-a-demethylase (PDB: 1EA1), using AutoDock-tools-1.5.6 and recorded the extent of H-bonding and the binding affinities. The preselected compounds via molecular docking were further tested for in vitro antimicrobial activity against five bacterial strains ( Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Staphylococcus aureus ) and two fungal strains ( Candida albicans and Cryptococcus neoformans ). It was observed that the compounds of this series possessed moderate antibacterial potential and high antifungal potential. Therefore studying these compounds will be a valuable starting point for further drug development and drug optimization