A Study of Serum Uric Acid Level in Patients with Psoriasis at a Tertiary Care Hospital in Eastern Nepal

M. Pradhan, A. Rai, S. Karki, Rajiv Ratan Singh Yadav, Sanjeev Mani Yadav
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Abstract

Background: Meta-analysis has shown that psoriasis is associated with hyperuricemia and its sequel.  So this study was done with objective to find out the association of serum uric acid level in patient with psoriasis and its correlation with severity of the disease. Materials and Methods: It was a prospective case control study conducted in the department of Dermatology, Nobel Medical College Teaching Hospital in eastern region of Nepal over a period of one year from Jan 2020 to Dec 2022 after approval of Intuitional review committee on Nobel Medical College Teaching Hospital. The diagnosis of the disease for the cases were done by clinical examination and biopsy when needed. 50 cases and 50 control sample were taken for the study. Psoriasis Area Severity Index was calculated for the cases and serum uric level was measured for both cases and control. Results: The mean serum uric level in psoriatic patients was 6.16 ± 1.64mg/dl with range of 4 to 11 mg/dl and that of control group was 5.39 ± 1.60 mg/dl with the range of 2 to 9mg/dl.  Mean serum uric acid level in psoriatic group was significantly higher than in control group with p value of 0.002 and there was positive correlation between severity of psoriasis with serum uric acid level(p=0.001). Conclusion: Psoriasis was associated with hyperuricemia in psoriasis patients.  
尼泊尔东部三级医院银屑病患者血清尿酸水平的研究
背景:荟萃分析显示银屑病与高尿酸血症及其后遗症相关。本研究旨在探讨银屑病患者血清尿酸水平与病情严重程度的关系。材料与方法:经诺贝尔医学院教学医院机构审查委员会批准,于2020年1月至2022年12月在尼泊尔东部地区诺贝尔医学院教学医院皮肤内科进行为期一年的前瞻性病例对照研究。本组病例均通过临床检查及必要时活检确诊。选取50例病例和50例对照样本进行研究。计算病例的银屑病严重程度指数,并测量病例和对照组的血清尿酸水平。结果:银屑病患者血清尿酸均值为6.16±1.64mg/dl,范围为4 ~ 11 mg/dl;对照组为5.39±1.60 mg/dl,范围为2 ~ 9mg/dl。银屑病组患者血清尿酸水平显著高于对照组(p值为0.002),银屑病严重程度与血清尿酸水平呈正相关(p=0.001)。结论:银屑病患者与高尿酸血症相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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