Inflammation induced PD-L1-specific T cells

IF 4.1 Q2 CELL BIOLOGY

Cell Stress Pub Date : 2019-09-13 DOI:10.15698/cst2019.10.201

Shamaila Munir, M. Lundsager, M. Jørgensen, M. Hansen, Trine H Petersen, C. Bonefeld, C. Friese, Ö. Met, P. Straten, M. Andersen

引用次数: 13

Abstract

PD-L1-specific T cells are a natural part of the T-cell repertoire in humans. Hence, we have previously described spontaneous CD8+ and CD4+ T-cell reactivity against PD-L1 in the peripheral blood of patients with various cancers as well as in healthy donors. It is well described that the expression of the PD-L1 protein is introduced in cells by pro-inflammatory cytokines, e.g. IFN-γ. In the current study, we were able to directly link inflammation with PD-L1-specific T cells by showing that inflammatory mediators such as IFN-γ generate measurable numbers of PD-L1-specific T cells in human PBMCs as well as in in vivo models. These PD-L1-specific T cells can vigorously modulate the cell compartments of the local environment. PD-L1-specific T cells may be important for immune homeostasis by sustaining the ongoing inflammatory response by the suppression of regulatory cell function both directly and indirectly.

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炎症诱导的PD-L1特异性T细胞

pd - l1特异性T细胞是人类T细胞库的自然组成部分。因此，我们之前已经描述了各种癌症患者和健康供者外周血中自发的CD8+和CD4+ t细胞对PD-L1的反应性。已经很好地描述了PD-L1蛋白的表达是通过促炎细胞因子(如IFN-γ)引入细胞的。在目前的研究中，我们能够直接将炎症与pd - l1特异性T细胞联系起来，通过显示炎症介质如IFN-γ在人pbmc和体内模型中产生可测量数量的pd - l1特异性T细胞。这些pd - l1特异性T细胞可以大力调节局部环境的细胞区室。pd - l1特异性T细胞可能通过直接或间接抑制调节细胞功能来维持持续的炎症反应，从而对免疫稳态起重要作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Stress Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (miscellaneous)

CiteScore

13.50

自引率

0.00%

发文量

审稿时长

15 weeks

期刊介绍： Cell Stress is an open-access, peer-reviewed journal that is dedicated to publishing highly relevant research in the field of cellular pathology. The journal focuses on advancing our understanding of the molecular, mechanistic, phenotypic, and other critical aspects that underpin cellular dysfunction and disease. It specifically aims to foster cell biology research that is applicable to a range of significant human diseases, including neurodegenerative disorders, myopathies, mitochondriopathies, infectious diseases, cancer, and pathological aging. The scope of Cell Stress is broad, welcoming submissions that represent a spectrum of research from fundamental to translational and clinical studies. The journal is a valuable resource for scientists, educators, and policymakers worldwide, as well as for any individual with an interest in cellular pathology. It serves as a platform for the dissemination of research findings that are instrumental in the investigation, classification, diagnosis, and therapeutic management of major diseases. By being open-access, Cell Stress ensures that its content is freely available to a global audience, thereby promoting international scientific collaboration and accelerating the exchange of knowledge within the research community.