Levothyroxine dosages less than 2.4 μg/kg/day at 1 year and 1.3 μg/kg/day at 3 years of age may predict transient congenital hypothyroidism

IF 1 Q4 ENDOCRINOLOGY & METABOLISM
S. Higuchi, Y. Hasegawa
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引用次数: 10

Abstract

Abstract. Significant differences in levothyroxine (LT4) dosages for congenital hypothyroidism (CH), which can be permanent (P-CH) or transient (T-CH), and their respective cutoff values have been reported. In Japanese children, however, these values are unknown, and were thus determined in this retrospective single-center study, which included 34 patients— 19 with P-CH and 15 with T-CH. The LT4 dosages of the two groups at ages 1 and 3 yr were compared, and receiver operating characteristic (ROC) analysis was performed to identify the cutoff dosages. The results showed that the LT4 dosages of the P-CH and T-CH groups differed significantly at both ages. When LT4 dosage cutoff at 1 yr of age was set at 2.4 μg/kg/d, the sensitivity and specificity were 93% and 74%, respectively, and when it was set at 1.3 μg/kg/d at 3 yr of age, they were 80% and 84%, respectively, suggesting that when LT4 dosages are ≤2.4 μg/kg/d at 1 yr and ≤1.3 μg/kg/d at 3 yr of age, T-CH should be suspected.
1岁时左旋甲状腺素剂量低于2.4 μg/kg/天,3岁时低于1.3 μg/kg/天可预测一过性先天性甲状腺功能减退
摘要先天性甲状腺功能减退症(CH)的左甲状腺素(LT4)剂量存在显著差异,可能是永久性的(P-CH)或短暂性的(T-CH),以及它们各自的临界值。然而,在日本儿童中,这些值是未知的,因此在这项回顾性单中心研究中确定了这些值,该研究包括34名患者——19名P-CH患者和15名T-CH患者。比较两组在1岁和3岁时的LT4剂量,并进行受试者工作特性(ROC)分析以确定截止剂量。结果表明,P-CH和T-CH组的LT4剂量在两个年龄段都有显著差异。当LT4在1岁时的剂量截止值设定为2.4μg/kg/d时,敏感性和特异性分别为93%和74%,当LT4设定为1.3μg/kg/d3岁时,它们分别为80%和84%,这表明当LT4剂量在1岁≤2.4μg/kkg/d和≤1.3μg/kkg/d3岁时宜怀疑T-CH。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Clinical Pediatric Endocrinology
Clinical Pediatric Endocrinology ENDOCRINOLOGY & METABOLISM-
CiteScore
2.40
自引率
7.10%
发文量
34
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