The Synthesis of Australine and its Stereoisomers as Naturally Pyrrolizidine Alkaloids

Abstract

Natural products are important from researchers’ perspectives due to their importance and applicability. Polyhydroxylated pyrrolizidine alkaloids are sugar mimics and received a growing interest in the last few years. Australine is a naturally polyhydroxylated pyrrolizidine, which was isolated from the seeds of Castanospermum austral, and exhibits potent biological activities such as inhibited glycosidases, as well as anti-virus, and anti-HIV activities. Thus, there is a considerable deal of interest in the synthesis of these classes of compounds. Different synthetic strategies and methodologies for the preparation of Australine and its stereoisomers were considered.