A Study of Lipid Profile in Obese Hypertensive Subjects

Abstract

Background: Obesity is a significant risk factor for metabolic syndrome in adults. Central fat distributiongreatly alters the lipid profile and induces atherogenic dyslipidemia even in normoglycaemic, nonhypertensivesubjects.Aim and Objectives: Hence, the aim of the present study to assess lipid profile changes in non-obesehypertensive subjects. Obesity, hypertension and dyslipidemia are the three highly significant risk factorfor the deranged lipid profile. Obesity can be defined as excess accumulation of body fat arising froma sustained or a periodic positive energy balance that when energy intake exceeds energy expenditure1.Indicators of overweight are useful in the diagnosis and management of obesity in both children and adults.Material & Methods: This study was conducted on newly diagnosed cases of essential hypertensionattending medical outdoor of M.G.M. Medical College, Kisangani. A complete clinical examinationincluding laboratory investigation was done to exclude any systemic or other diseases which are likely toaffect blood lipid levels directly or indirectly.Results- The association between dyslipidaemia, obesity and hypertension is well establishedand all havebeen found to be major risk factor for the development of CAD, a leading cause of visits to physician andcause of death .Conclusion: Our study was envisaged to know the effect of obesity on lipid profile profile only inhypertensive and not in general population, and the study found some definite but paradoxical effects.These are that in obesity on a background of hypertension, the total and LDL cholesterol as also the HDLcholesterol are decreased, but on use other hand, the value of VLDL cholesterol and triglycerides are grosslyand significantly increased. These finding have two major Clinical implications in that obese hypertensiveswill be more prone to metabolic syndrome and type 2 diabetes mellitus, and steps should be taken to preventthem accordingly and also apart from statins one should treat the obese hypertensives with fibrates, fatrestriction and physical exercise also.