The relationship between neopterin and hepatitis B surface antigen positivity

IF 0.5 4区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Pteridines Pub Date : 2018-03-02 DOI:10.1515/pteridines-2018-0001

S. Ünüvar, Hamza Aslanhan, Z. Tanrıverdi, Fuat Karakuş

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引用次数: 4

Abstract

Hepatitis B is a life-threatening viral liver infection caused by the hepatitis B virus. Neopterin is regarded as an immunologic biomarker of several diseases related to activation of the cellular immune system. Hepatitis B infection is associated with increased production of cellular immune system markers. We aimed to investigate whether there is a relationship between hepatitis B surface antigen-positivity (HBsAg +) and neopterin to determine the role of neopterin in the early diagnosis of hepatitis B infections. Seventy-two HBsAg (+) patients with normal liver function tests and forty-three controls were included in the study. Neopterin levels were 17.6 ± 0.13 nmol/L in HBsAg (+) patients; and 9.12 ± 0.09 nmol/L in infection-free controls, respectively. Compared to the control group, a statistically significant increase (p < 0.001) in the serum neopterin levels of the patients was observed. No significant relationship was determined between neopterin levels and age/sex (both, p > 0.05). With overstimulation of interferon-gamma, the production of neopterin increases by monocytes/macrophages. Likewise with other diseases associated with an activated cellular immune system, this study shows that neopterin can be a predictive biomarker for persistent carriers of hepatitis B infection.

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新蝶呤与乙型肝炎表面抗原阳性的关系

乙型肝炎是由乙型肝炎病毒引起的一种危及生命的病毒性肝脏感染。新蝶呤被认为是与细胞免疫系统激活有关的几种疾病的免疫生物标志物。乙型肝炎感染与细胞免疫系统标志物的产生增加有关。我们旨在研究乙肝表面抗原阳性(HBsAg +)与新蝶呤之间是否存在关系，以确定新蝶呤在乙型肝炎感染早期诊断中的作用。72例肝功能检查正常的HBsAg(+)患者和43例对照组纳入研究。HBsAg(+)组新蝶呤水平为17.6±0.13 nmol/L;无感染对照组为9.12±0.09 nmol/L。与对照组相比，患者血清新蝶呤水平有统计学意义升高(p < 0.001)。新蝶呤水平与年龄/性别无显著关系(p < 0.05)。随着干扰素γ的过度刺激，单核细胞/巨噬细胞产生新蝶呤增加。与其他与活化的细胞免疫系统相关的疾病一样，这项研究表明，新蝶呤可以作为乙型肝炎感染持续性携带者的预测性生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pteridines 生物-生化与分子生物学

CiteScore

1.20

自引率

25.00%

发文量

审稿时长

>12 weeks

期刊介绍： Pteridines is an open acess international quarterly journal dealing with all aspects of pteridine research. Pteridines are heterocyclic fused ring compounds involved in a wide range of biological functions from the color on butterfly wings to cofactors in enzyme catalysis to essential vitamins. Of the pteridines, 5,6,7,8-tetrahydrobiopterin is the necessary cofactor of several aromatic amino acid monoxygenases, the nitric oxide synthases and glyceryl ether monoxygenase (GEMO). Neopterin plays an essential role in the immune system and is an important biomarker in laboratory medicine for diseases such as HIV, cardiovascular disease, malignant tumors, among others. Topics: -Neopterin, dihydroneopterin, monapterin- Biopterin, tetrahydrobiopterin- Folates, antifolates, riboflavin- Phenylalanine, tyrosine, phenylketonuria, serotonin, adrenalin, noradrenalin, L-DOPA, dopamine, related biogenic amines- Phenylalanine hydroxylase, tyrosine hydroxylase, tryptophan hydroxylase, nitric oxide synthases (iNOS), alkylglycerol monooxygenase (AGMO), dihydropterin reductase, sepiapterin reductase- Homocysteine, mediators of inflammation, redox systems, iron.