Autophagy and Transforming Growth Factor Beta1 in Renal Tubular Epithelia Cells

Abstract

Transforming growth factor beta1 (TGF-β1) is regarded as the important factor in many fibrotic kidney diseases. Autophagy is a vital mechanism which maintains intracellular homeostasis in eukaryotic cells and involves in various renal physiologic and pathological processes. Current studies indicate that autophagy in renal tubular epithelial cells serves as a renoprotective mechanism which modulates the course of diverse kidney disease. Thus, this review aims to show the possible linkage between TGF-β1 and autophagy in the renal tubular epithelial cells. RevieW ARTiCLe