RETRACTED ARTICLE: Asiatic acid attenuates pre-neoplastic lesions, oxidative stress, biotransforming enzymes and histopathological alterations in 1,2-dimethylhydrazine-induced experimental rat colon carcinogenesis

IF 2.8 4区医学 Q2 TOXICOLOGY

Toxicology Mechanisms and Methods Pub Date : 2017-01-11 DOI:10.1080/15376516.2016.1273422

Aktarul Islam Siddique, V. Mani, S. Arivalagan, N. Thomas, N. Namasivayam

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引用次数: 22

Abstract

Abstract Statement of Retraction: Asiatic acid attenuates pre-neoplastic lesions, oxidative stress, biotransforming enzymes and histopathological alterations in 1,2-dimethylhydrazine-induced experimental rat colon carcinogenesis We, the Editors and Publishers of Toxicology Mechanisms and Methods have retracted the following article:  Aktarul Islam Siddique, Vijay Mani, Sivaranjani Arivalagan, Nisha Susan Thomas & Nalini Namasivayam (2017) Asiatic acid attenuates pre-neoplastic lesions, oxidative stress, biotransforming enzymes and histopathological alterations in 1,2-dimethylhydrazine-induced experimental rat colon carcinogenesis, Toxicology Mechanisms and Methods, 27:2, 136-150, DOI: 10.1080/15376516.2016.1273422 The article is being retracted due to image manipulation in Figures 3 and 9, as follows: Figure 3: Panel E is a subsection of Panel B; Figure 3: Panels C and D appear to contain clone stamps; Figure 9: Panels A and B are the same image, with the frame of reference shifted; Figure 9: Panels Ai and Bi are the same image, with the frame of reference shifted; Figure 9: Panels E and F contain an overlapping section (panel E lower right corner, panel F upper left corner); Figure 9: Panels Ei and Fi contain an overlapping section (panel Ei lower right corner, panel Fi upper left corner). These findings are not explained by the content of the article and the authors were not able to provide original data that would support the integrity of their research. We have been informed in our decision-making by our policy on publishing ethics and integrity and the COPE guidelines on retractions. The retracted article will remain online to maintain the scholarly record, but it will be digitally watermarked on each page as “Retracted”. 

查看原文本刊更多论文

文章摘要:在1,2-二甲基肼诱导的实验大鼠结肠癌中，亚洲酸可减轻肿瘤前病变、氧化应激、生物转化酶和组织病理学改变

摘要撤回声明:我们，毒理学机制和方法的编辑和出版商已经撤销了以下文章: Aktarul Islam Siddique, Vijay Mani, Sivaranjani Arivalagan, Nisha Susan Thomas & Nalini Namasivayam(2017)亚洲酸减弱肿瘤前病变，氧化应激，生物转化酶和1,2-二甲基肼诱导的实验性大鼠结肠癌的组织病理学改变，毒理学机制和方法，27:2,136-150,DOI: 10.1080/15376516.2016.1273422由于图3和图9中的图像处理，文章被撤回，如下图所示:图3:图E是图B的一个小节;图三:嵌板C及D似乎是仿制邮票;图9:面板A和B为同一张图像，参考帧移位;图9:面板Ai和面板Bi为同一张图像，只是参照系移位了;图9:面板E和F包含重叠部分(面板E右下角，面板F左上角);图9:面板Ei和Fi包含重叠的部分(面板Ei右下角，面板Fi左上角)。这些发现不能用文章的内容来解释，作者也不能提供原始数据来支持他们研究的完整性。我们的出版道德和诚信政策以及COPE关于撤稿的指导方针已经通知了我们的决策。 撤回的文章将保留在网上，以保持学术记录，但将在每页上以数字水印标记为“撤回”。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Toxicology Mechanisms and Methods TOXICOLOGY-

自引率

3.10%

发文量

期刊介绍： Toxicology Mechanisms and Methods is a peer-reviewed journal whose aim is twofold. Firstly, the journal contains original research on subjects dealing with the mechanisms by which foreign chemicals cause toxic tissue injury. Chemical substances of interest include industrial compounds, environmental pollutants, hazardous wastes, drugs, pesticides, and chemical warfare agents. The scope of the journal spans from molecular and cellular mechanisms of action to the consideration of mechanistic evidence in establishing regulatory policy. Secondly, the journal addresses aspects of the development, validation, and application of new and existing laboratory methods, techniques, and equipment. A variety of research methods are discussed, including: In vivo studies with standard and alternative species In vitro studies and alternative methodologies Molecular, biochemical, and cellular techniques Pharmacokinetics and pharmacodynamics Mathematical modeling and computer programs Forensic analyses Risk assessment Data collection and analysis.