Effects of coconut oil (Cocos nucifera) and sesame oils (Sesamum indicum L.) on rapeseed powder induced changes of cardio-hepatic enzymes in Wistar rats.

4区医学 Q4 Agricultural and Biological Sciences

Progress in Nutrition Pub Date : 2018-08-06 DOI:10.23751/PN.V20I1-S.5543

H. Rahman, Shaikh Shahinur Rahman

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引用次数: 0

Abstract

Purpose: Rapeseed oil contains high percentage of erucic acid which causes cardio-hepatic toxicity. Methods: In this study, different doses of sesame oil (SO) and coconut oil (CO) were mixed with constant dose of rapeseed oil and fed to Wistar rats for 6 weeks. After the experimental period, abdomen aortic blood was collected and serum enzymes level such as CK-MB, SGOT and SGPT were measured. Results: Rapeseed oil not only increased SGPT enzyme level over control diet but also elevated CK-MB and SGOT significantly. Whereas, sesame oil and coconut oil showed protective effect against rapeseed oil induced cardio-hepatic enzymes. Moreover, higher doses of both oils represented better effect against rapeseed oil toxicity. Although CO and SO significantly decreased serum CK-MB, SGOT and SGPT activities, coconut oil had greater effect on cardiac enzymes like CK-MB while sesame oil were more significant for SGPT and SGOT. Conclusion: Therefore, the ameliorating effects of sesame oil and coconut oil trimmed down the toxic effects of rapeseed oil in rats.

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椰子油和芝麻油对菜籽粉诱导Wistar大鼠肝心酶变化的影响。

用途:菜籽油中含有高浓度的芥酸，对心脏和肝脏有毒性。方法:将不同剂量的芝麻油(SO)和椰子油(CO)与等剂量的菜籽油混合，饲喂Wistar大鼠6周。实验结束后采集腹主动脉血，测定血清CK-MB、SGOT、SGPT等酶水平。结果:与对照组相比，菜籽油不仅显著提高了SGPT酶水平，而且显著提高了CK-MB和SGOT水平。芝麻油和椰子油对菜籽油诱导的肝心酶有保护作用。两种油的剂量越高，抗菜籽油毒性效果越好。虽然CO和SO显著降低血清CK-MB、SGOT和SGPT活性，但椰子油对CK-MB等心脏酶的影响更大，芝麻油对SGPT和SGOT的影响更显著。结论:芝麻油和椰子油的改善作用明显减弱菜籽油对大鼠的毒性作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Progress in Nutrition 医学-营养学

CiteScore

1.40

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Progress in Nutrition was founded in 1999 as an independent magazine, a multidisciplinary approach, dedicated to issues of nutrition and metabolism.