Molecular Approach Towards Screening of Biological Targets of Berberine and its Production Sources

Q3 Pharmacology, Toxicology and Pharmaceutics

Current Trends in Biotechnology and Pharmacy Pub Date : 2021-05-31 DOI:10.5530/CTBP.2021.2.16

Jhansi Preetham Garrepelly, L. KiranmayiPYN, Thanuja Bandari, Rajeswara Reddy Erva

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引用次数: 1

Abstract

Traditional medicine dating back to centuries ago has been used to treat several ailments of humans. Berberine is a chemical compound that is found in plants which is being used in the form of drugs to work against various diseases. For optimum production of Berberine suitable plant species must be selected out of Coptis japonica and Argemona mexicana which are high yielding. From the pathway of Berberine production it is known that more the amount of substrate Canadine gives more amount of Berberine. The objective of this work is to compare the Canadine production efficiency among Coptis japonica and Argemona mexicana by molecular level studies for both the species. It is concluded that the enzyme, (S)-canadine synthase from Argemona mexicana is more efficient towards the production of (S)-canadine which in turn lead to Berberine production. Later the efficiency of Berberine against various disease targets is tested by molecular docking approach under same experimental conditions. Molecular docking results conferred the efficiency of Berberine in the treatment of gastric cancer over the other diseases.

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小檗碱生物靶点筛选及其产源的分子方法研究

传统医学可以追溯到几个世纪前，已经被用来治疗人类的几种疾病。小檗碱是一种在植物中发现的化合物，它以药物的形式被用来治疗各种疾病。为了使小檗碱的产量达到最佳，必须从黄连和墨西哥姜中选择适宜的高产植物品种。从小檗碱的产生途径可知，底物加拿大碱的量越多，小檗碱的量就越多。本研究的目的是通过分子水平的研究比较黄连和墨西哥黄连的产加拿大碱效率。综上所述，墨西哥Argemona mexicana的(S)-canadine合成酶更有效地生产(S)-canadine，进而生产小檗碱。随后在相同的实验条件下，采用分子对接的方法检测小檗碱对多种疾病靶点的药效。分子对接结果表明，小檗碱治疗胃癌的效果优于其他疾病。

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来源期刊

Current Trends in Biotechnology and Pharmacy Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

0.70

自引率

0.00%

发文量

期刊介绍： The Association of Biotechnology and Pharmacy (ABAP) will be useful to form a forum for scientists so that they can bring together to discuss and find scientific solutions to the problems of society. The annual meetings will help the members to share their knowledge and publish their research knowledge particularly by members and fellows of the Association and special care will be taken to provide an opportunity for young scientists. Besides this the association is planned to organize symposia, seminars and workshops on current developments of Biotechnology and Pharmacy particularly on the subject of current scientific interest, and the proceedings of which will be published regularly. And in view of the vast development of science and to disseminate the problems in publication of research work, an international journal of Current Trends in Biotechnology and Pharmacy has been started by ABAP.