The value of MRI in evaluating the therapeutic effect of desmoid-type fibromatosis

Q4 Medicine

Zhonghua fang she xue za zhi Chinese journal of radiology Pub Date : 2020-01-10 DOI:10.3760/CMA.J.ISSN.1005-1201.2020.01.008

Hui-ci Zhu, Xiao-Ting Li, Shu Li, Xiaoyan Zhang, Zhen Guan, Yingshi Sun

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Abstract

Objective To compare the characteristics of MRI signals in different therapeutic effect of desmoid-type fibromatosis (DF). Methods One hundred and twenty-four DF patients with pathologically proven postoperative recurrent lesions from Peking University Cancer Hospital from 2008 to 2015 were enrolled in the study. All patients had baseline MRI scans, followed by once MRI scan at least every six months, and the follow-up period was three years. All patients had MRI images at the end of the third year. The therapeutic effect was evaluated by response evaluation criteria in solid tumors (RECIST) criteria, and the patients were divided into three groups: progressive disease (PD), stable disease (SD) and partial response (PR). Differences in features in the PD, SD, and PR groups were compared using one-way analysis of variance, Kruskal-Wallis, or Chi-square test. Multiple comparisons were performed using Bonferroni to correct P values. The spearman correlation coefficient was used to test the correlation between signal score and tumor maximum diameter. Results Among the 124 patients, 17 experienced PD, 37 exhibited SD and 70 exhibited PR. There were no significant differences in age, gender distribution and the location of lesion among three groups (P>0.05). The difference of treatment strategies was statistically significant (P 0.05). At the last follow-up MRI scan, the T2 signal scores, the changes of T2 signal, the scores of enhancement and the changes of enhancement of the PD, SD, and PR groups were significantly different among three groups (P<0.05). At the last follow-up MRI scan, the tumor maximum diameter was positively correlated with the score of T2 signal (r=0.434, P<0.01), and the tumor maximum diameter was positively correlated with the score of enhancement (r=0.743, P<0.01). Conclusion MRI has great value in evaluating the therapeutic effect of DF. Key words: Magnetic resonance imaging; Desmoid-type fibromatosis; Therapeutic effect evaluation

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MRI在评价纤维瘤病疗效中的价值

目的比较不同疗效的硬纤维样纤维瘤病（DF）的MRI信号特征。方法选择2008～2015年北京大学癌症医院经病理证实的术后复发性DF患者124例。所有患者都进行了基线MRI扫描，然后至少每六个月进行一次MRI扫描，随访期为三年。所有患者在第三年结束时都有MRI图像。采用实体瘤反应评价标准（RECIST）评价疗效，将患者分为三组：进展性疾病（PD）、稳定性疾病（SD）和部分反应（PR）。使用单向方差分析、Kruskal-Wallis或卡方检验比较PD、SD和PR组的特征差异。使用Bonferroni进行多次比较以校正P值。spearman相关系数用于检验信号评分与肿瘤最大直径之间的相关性。结果124例患者中，17例出现PD，37例出现SD，70例出现PR。三组患者的年龄、性别分布和病变部位差异无统计学意义（P>0.05）。治疗策略差异有统计学意义（P<0.05），PD、SD和PR组的增强评分和增强变化在三组之间有显著差异（P<0.05）。在最后一次随访MRI扫描时，肿瘤最大直径与T2信号评分呈正相关（r=0.434，P<0.01），肿瘤最大直径与增强评分呈正相关（r=0.743，P<0.01）。结论MRI对评价DF的疗效有重要价值。关键词：磁共振成像；筛状纤维瘤病；疗效评价

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来源期刊

Zhonghua fang she xue za zhi Chinese journal of radiology Medicine-Radiology, Nuclear Medicine and Imaging

CiteScore

0.30

自引率

0.00%

发文量

10639