Predictive value of stimulated thyroglobulin before the first 131I ablation for metastasis of differentiated thyroid carcinoma in children and adolescents

中华核医学与分子影像杂志 Pub Date : 2019-11-25 DOI:10.3760/CMA.J.ISSN.2095-2848.2019.11.005

Xian-min Ding, Ying Ding, Sen Wang, Guang Yang, Fu-qiang Zhang, Deyu Li, Qiang Li, Wen-liang Li

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Abstract

Objective To investigate the clinical value of pre-ablation stimulated thyroglobulin (psTg) in the prediction of metastasis of differentiated thyroid carcinoma (DTC) in children and adolescents. Methods The study included 51 children and adolescent patients (20 males, 31 females, age: 8-18(13.5±3.0) years) with DTC who had undergone total thyroidectomy and lymphadenectomy and were going to have the first 131I ablation therapy from March 2012 to December 2017 in the Affiliated Cancer Hospital of Zhengzhou University. Patients′ serum thyroglobulin antibody (TgAb) levels were normal. They were divided into M0 group (without metastasis) and M1 group (with metastasis). The psTg difference between the two groups was compared using Mann-Whitney U test. The receiver operating characteristic (ROC) curves and diagnostic critical point (DCP) of psTg for the metastasis prediction were analyzed. Results The psTg levels of M0 group (n=20) and M1 group (n=31) were 5.76(3.38, 18.51) μg/L and 280.46(37.66, 470.00) μg/L, respectively, and the difference between the two groups was statistically significant (U=41, P<0.05). The area under the ROC curve of psTg was 0.934 (95% CI: 0.869-0.999) with the sensitivity, specificity and accuracy of 80.6%(25/31), 100%(20/20) and 88.2%(45/51) respectively, with the DCP value of 31.98 μg/L. Conclusion The psTg value detected before the first 131I treatment has an important predictive value for postoperative metastasis of DTC in children and adolescents. Key words: Thyroid neoplasms; Neoplasm metastasis; Thyroglobulin; Radiotherapy; Iodine radioisotopes; Child; Adolescent

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首次131I消融前促甲状腺球蛋白对儿童和青少年分化型甲状腺癌转移的预测价值

目的探讨消融术前刺激甲状腺球蛋白（psTg）预测儿童青少年分化型甲状腺癌（DTC）转移的临床价值。方法对郑州大学附属癌症医院2012年3月至2017年12月收治的51例DTC患儿（男20例，女31例，年龄8-18（13.5±3.0）岁）进行了甲状腺全切除术和淋巴结切除术，并将进行首次131I消融治疗。患者血清甲状腺球蛋白抗体（TgAb）水平正常。分为M0组（无转移）和M1组（有转移）。使用Mann-Whitney U检验比较两组之间的psTg差异。分析psTg的受试者工作特性（ROC）曲线和用于预测转移的诊断临界点（DCP）。结果M0组（n=20）和M1组（n=31）的psTg水平分别为5.76（3.38，18.51）μg/L和280.46（37.66，470.00）μg/L，两组差异有统计学意义（U=41，P<0.05），DCP值分别为31.98μg/L和88.2%（45/51）。结论首次131I治疗前检测的psTg值对儿童青少年DTC术后转移有重要的预测价值。关键词：甲状腺肿瘤；肿瘤转移；甲状腺球蛋白；放射治疗；碘放射性同位素；儿童；青少年

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来源期刊

中华核医学与分子影像杂志核医学，分子影像

自引率

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发文量

5088

期刊介绍： Chinese Journal of Nuclear Medicine and Molecular Imaging (CJNMMI) was established in 1981, with the name of Chinese Journal of Nuclear Medicine, and renamed in 2012. As the specialized periodical in the domain of nuclear medicine in China, the aim of Chinese Journal of Nuclear Medicine and Molecular Imaging is to develop nuclear medicine sciences, push forward nuclear medicine education and basic construction, foster qualified personnel training and academic exchanges, and popularize related knowledge and raising public awareness. Topics of interest for Chinese Journal of Nuclear Medicine and Molecular Imaging include: -Research and commentary on nuclear medicine and molecular imaging with significant implications for disease diagnosis and treatment -Investigative studies of heart, brain imaging and tumor positioning -Perspectives and reviews on research topics that discuss the implications of findings from the basic science and clinical practice of nuclear medicine and molecular imaging - Nuclear medicine education and personnel training - Topics of interest for nuclear medicine and molecular imaging include subject coverage diseases such as cardiovascular diseases, cancer, Alzheimer’s disease, and Parkinson’s disease, and also radionuclide therapy, radiomics, molecular probes and related translational research.