{"title":"Phytochemicals, α-glucosidase and α-amylase Inhibitory Efficiency of Brittle Wort (Chara corallina) Extract","authors":"W. Chankaew, Uraiwan Phetkul, Rawinipa Srimoon","doi":"10.55003/cast.2023.257626","DOIUrl":null,"url":null,"abstract":"This research is the first to evaluate brittle wort (Chara corallina) extract for phytochemical content and inhibitory effects against a-glucosidase and a-amylase activities. An ethanolic extract of C. corallina had the strongest enzyme inhibitory effect. The inhibition efficiencies of all extracts against a-amylase were more potent than those against a-glucosidase, with IC50 values of 8.43±0.18 mg/mL against a-glucosidase and 1.78±0.07 against a-amylase. Inhibition efficiency was related to total phenolic content, DPPH radical scavenging activity, ATBS radical scavenging activity and metal-chelation activity of the extracts. Phytochemical screening of the ethanolic extract demonstrated the presence of the triterpenoid β-sitosterol. These findings provide useful supporting data for further applications of C. corallina extract.","PeriodicalId":36974,"journal":{"name":"Current Applied Science and Technology","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Applied Science and Technology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.55003/cast.2023.257626","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Agricultural and Biological Sciences","Score":null,"Total":0}
引用次数: 0
Abstract
This research is the first to evaluate brittle wort (Chara corallina) extract for phytochemical content and inhibitory effects against a-glucosidase and a-amylase activities. An ethanolic extract of C. corallina had the strongest enzyme inhibitory effect. The inhibition efficiencies of all extracts against a-amylase were more potent than those against a-glucosidase, with IC50 values of 8.43±0.18 mg/mL against a-glucosidase and 1.78±0.07 against a-amylase. Inhibition efficiency was related to total phenolic content, DPPH radical scavenging activity, ATBS radical scavenging activity and metal-chelation activity of the extracts. Phytochemical screening of the ethanolic extract demonstrated the presence of the triterpenoid β-sitosterol. These findings provide useful supporting data for further applications of C. corallina extract.